Matches in SemOpenAlex for { <https://semopenalex.org/work/W2126207811> ?p ?o ?g. }
- W2126207811 endingPage "9" @default.
- W2126207811 startingPage "1" @default.
- W2126207811 abstract "Diabetic nephropathy is a leading cause of end-stage renal disease worldwide. The multipronged drug approach targeting blood pressure and serum levels of glucose, insulin, and lipids fails to fully prevent the onset and progression of diabetic nephropathy. Therefore, a new therapeutic target to combat diabetic nephropathy is required. Autophagy is a catabolic process that degrades damaged proteins and organelles in mammalian cells and plays a critical role in maintaining cellular homeostasis. The accumulation of proteins and organelles damaged by hyperglycemia and other diabetes-related metabolic changes is highly associated with the development of diabetic nephropathy. Recent studies have suggested that autophagy activity is altered in both podocytes and proximal tubular cells under diabetic conditions. Autophagy activity is regulated by both nutrient state and intracellular stresses. Under diabetic conditions, an altered nutritional state due to nutrient excess may interfere with the autophagic response stimulated by intracellular stresses, leading to exacerbation of organelle dysfunction and diabetic nephropathy. In this review, we discuss new findings showing the relationships between autophagy and diabetic nephropathy and suggest the therapeutic potential of autophagy in diabetic nephropathy." @default.
- W2126207811 created "2016-06-24" @default.
- W2126207811 creator A5030451172 @default.
- W2126207811 creator A5031134984 @default.
- W2126207811 creator A5044262228 @default.
- W2126207811 creator A5057537939 @default.
- W2126207811 creator A5063103432 @default.
- W2126207811 creator A5069516269 @default.
- W2126207811 date "2013-01-01" @default.
- W2126207811 modified "2023-10-12" @default.
- W2126207811 title "The Role of Autophagy in the Pathogenesis of Diabetic Nephropathy" @default.
- W2126207811 cites W1487064198 @default.
- W2126207811 cites W1593406565 @default.
- W2126207811 cites W1784425676 @default.
- W2126207811 cites W1918384196 @default.
- W2126207811 cites W1970637701 @default.
- W2126207811 cites W1974766032 @default.
- W2126207811 cites W1974778184 @default.
- W2126207811 cites W1978145149 @default.
- W2126207811 cites W1982635949 @default.
- W2126207811 cites W1987979328 @default.
- W2126207811 cites W1993643473 @default.
- W2126207811 cites W1994030315 @default.
- W2126207811 cites W1994817218 @default.
- W2126207811 cites W1994823455 @default.
- W2126207811 cites W1998399313 @default.
- W2126207811 cites W1998787508 @default.
- W2126207811 cites W1999477136 @default.
- W2126207811 cites W2001902542 @default.
- W2126207811 cites W2003503015 @default.
- W2126207811 cites W2006254543 @default.
- W2126207811 cites W2006544096 @default.
- W2126207811 cites W2007378287 @default.
- W2126207811 cites W2011211981 @default.
- W2126207811 cites W2011282245 @default.
- W2126207811 cites W2013381376 @default.
- W2126207811 cites W2015173256 @default.
- W2126207811 cites W2016040396 @default.
- W2126207811 cites W2017073557 @default.
- W2126207811 cites W2018652887 @default.
- W2126207811 cites W2020771162 @default.
- W2126207811 cites W2022451432 @default.
- W2126207811 cites W2022570265 @default.
- W2126207811 cites W2024184215 @default.
- W2126207811 cites W2024469019 @default.
- W2126207811 cites W2024782183 @default.
- W2126207811 cites W2025176940 @default.
- W2126207811 cites W2025665129 @default.
- W2126207811 cites W2026500266 @default.
- W2126207811 cites W2027785297 @default.
- W2126207811 cites W2030287946 @default.
- W2126207811 cites W2030667534 @default.
- W2126207811 cites W2031308048 @default.
- W2126207811 cites W2032950904 @default.
- W2126207811 cites W2034087770 @default.
- W2126207811 cites W2038007890 @default.
- W2126207811 cites W2039525732 @default.
- W2126207811 cites W2040280675 @default.
- W2126207811 cites W2046250764 @default.
- W2126207811 cites W2051429808 @default.
- W2126207811 cites W2051719011 @default.
- W2126207811 cites W2052343685 @default.
- W2126207811 cites W2052746044 @default.
- W2126207811 cites W2056137479 @default.
- W2126207811 cites W2056976690 @default.
- W2126207811 cites W2061166531 @default.
- W2126207811 cites W2074563683 @default.
- W2126207811 cites W2075391935 @default.
- W2126207811 cites W2080100430 @default.
- W2126207811 cites W2081057817 @default.
- W2126207811 cites W2084109336 @default.
- W2126207811 cites W2085586604 @default.
- W2126207811 cites W2090277882 @default.
- W2126207811 cites W2091754751 @default.
- W2126207811 cites W2094719535 @default.
- W2126207811 cites W2098985594 @default.
- W2126207811 cites W2101721772 @default.
- W2126207811 cites W2104040600 @default.
- W2126207811 cites W2106444069 @default.
- W2126207811 cites W2113432343 @default.
- W2126207811 cites W2115134069 @default.
- W2126207811 cites W2115742671 @default.
- W2126207811 cites W2117833492 @default.
- W2126207811 cites W2119399459 @default.
- W2126207811 cites W2127063807 @default.
- W2126207811 cites W2127916470 @default.
- W2126207811 cites W2130127620 @default.
- W2126207811 cites W2130542877 @default.
- W2126207811 cites W2132123065 @default.
- W2126207811 cites W2134138119 @default.
- W2126207811 cites W2135574023 @default.
- W2126207811 cites W2138256890 @default.
- W2126207811 cites W2138544728 @default.
- W2126207811 cites W2146124002 @default.
- W2126207811 cites W2150551377 @default.
- W2126207811 cites W2151170909 @default.
- W2126207811 cites W2153607816 @default.
- W2126207811 cites W2156144699 @default.