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• W2126222502 endingPage "2716" @default.
• W2126222502 startingPage "2707" @default.
• W2126222502 abstract "The steroid hormone Ecdysone is crucial for developmental cell death,proliferation and morphogenesis in Drosophila. Herein, we delineate a molecular pathway linking Ecdysone signalling to cell cycle regulation in the Drosophila developing wing. We present evidence that the Ecdysone-inducible zinc-finger transcription factor Crol provides a crucial link between the Ecdysone steroid hormone pathway and the Wingless (Wg)signalling pathway in Drosophila. We identified Crol as a strong enhancer of a wing phenotype generated by overexpression of the Wg-inducible cell cycle inhibitor Hfp. We demonstrate that Crol is required for cell cycle progression: crol mutant clones have reduced cell cycles and are removed by apoptosis, while upregulation of Crol overrides the Wg-mediated developmental cell cycle arrest in the zone of non-proliferating cells in the wing disc. Furthermore, we show that Crol acts to repress wgtranscription. We also show that overexpression of crol results in downregulation of Hfp, consistent with the identification of the crolmutant as a dominant enhancer of the Hfp overexpression phenotype. Taken together, our studies have revealed a novel mechanism for cell cycle regulation, whereby Crol links steroid hormone signals to Wg signalling and the regulation of crucial cell cycle targets." @default.
• W2126222502 created "2016-06-24" @default.
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• W2126222502 date "2008-08-15" @default.
• W2126222502 modified "2023-10-16" @default.
• W2126222502 title "The Ecdysone-inducible zinc-finger transcription factor Crol regulates Wg transcription and cell cycle progression in<i>Drosophila</i>" @default.
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• W2126222502 doi "https://doi.org/10.1242/dev.021766" @default.
• W2126222502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18614577" @default.
• W2126222502 hasPublicationYear "2008" @default.
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