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• W2126231182 abstract "Objective— Scavenger receptor class B type I (SR-BI)/apolipoprotein E (apoE) double knockout (dKO) mice exhibit many features of human coronary heart disease (CHD), including occlusive coronary atherosclerosis, cardiac hypertrophy, myocardial infarctions, and premature death. Here we determined the influence of B and T lymphocytes, which can contribute to atherosclerosis, ischemia–reperfusion injury, and cardiomyocyte death, on pathology in dKO mice. Method and Results— The lymphocyte-deficient SR-BI/apoE/recombination activating gene 2 (RAG2) triple knockout mice and corresponding dKO controls generated for this study exhibited essentially identical lipid-rich coronary occlusions, myocardial infarctions, cardiac dysfunction, and premature death (average lifespans 41.6±0.6 and 42.0±0.5 days, respectively). Conclusions— B and T lymphocytes and associated immunoglobulin-mediated inflammation are not essential for the development and progression of CHD in dKO mice. Strikingly, the dKO mice bred for this study (mixed C57BL/6×SV129×BALB/c background; strain 2) compared with the previously described dKO mice (75:25 C57BL/6:SV129 background; strain 1) had a shorter mean lifespan and steeper survival curve, characteristics especially attractive for studying the effects of environmental, pharmacological, and genetic manipulations on cardiac pathophysiology." @default.
• W2126231182 created "2016-06-24" @default.
• W2126231182 creator A5016136470 @default.
• W2126231182 creator A5028038671 @default.
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• W2126231182 date "2005-04-01" @default.
• W2126231182 modified "2023-09-25" @default.
• W2126231182 title "Lymphocytes Are Not Required for the Rapid Onset of Coronary Heart Disease in Scavenger Receptor Class B Type I/Apolipoprotein E Double Knockout Mice" @default.
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• W2126231182 doi "https://doi.org/10.1161/01.atv.0000158310.64498.ac" @default.
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