FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2126231439> ?p ?o ?g. }

• W2126231439 endingPage "6749" @default.
• W2126231439 startingPage "6741" @default.
• W2126231439 abstract "Abstract ATP, which serves as a mediator of intramacrophage signaling pathways through purinoceptors, is known to potentiate macrophage antimycobacterial activity. In this study we examined the effects of ATP in potentiating host resistance to Mycobacterium avium complex (MAC) infection in mice undergoing treatment with a drug regimen using clarithromycin and rifamycin and obtained the following findings. First, the administration of ATP in combination with the clarithromycin and rifamycin regimen accelerated bacterial elimination in MAC-infected mice without causing changes in the histopathological features or the mRNA expression of pro- or anti-inflammatory cytokines from those in the mice not given ATP. Second, ATP potentiated the anti-MAC bactericidal activity of macrophages cultivated in the presence of clarithromycin and rifamycin. This effect of ATP was closely related to intracellular Ca2+ mobilization and was specifically blocked by a cytosolic phospholipase A2 (cPLA2) inhibitor, arachidonyl trifluoromethylketone. Third, intramacrophage translocation of membranous arachidonic acid molecules to MAC-containing phagosomes was also specifically blocked by arachidonyl trifluoromethylketone. In the confocal microscopic observation of MAC-infected macrophages, ATP enhanced the intracellular translocation of cPLA2 into MAC-containing phagosomes. These findings suggest that ATP increases the host anti-MAC resistance by potentiating the antimycobacterial activity of host macrophages and that the cPLA2-dependent generation of arachidonic acid from the phagosomal membrane is essential for such a phenomenon." @default.
• W2126231439 created "2016-06-24" @default.
• W2126231439 creator A5001206797 @default.
• W2126231439 creator A5002646374 @default.
• W2126231439 creator A5031321349 @default.
• W2126231439 creator A5034851812 @default.
• W2126231439 creator A5054587936 @default.
• W2126231439 creator A5056091318 @default.
• W2126231439 creator A5057957787 @default.
• W2126231439 creator A5058553369 @default.
• W2126231439 date "2005-11-15" @default.
• W2126231439 modified "2023-10-03" @default.
• W2126231439 title "Combined Effects of ATP on the Therapeutic Efficacy of Antimicrobial Drug Regimens against <i>Mycobacterium avium</i> Complex Infection in Mice and Roles of Cytosolic Phospholipase A2-Dependent Mechanisms in the ATP-Mediated Potentiation of Antimycobacterial Host Resistance" @default.
• W2126231439 cites W1484385846 @default.
• W2126231439 cites W1542025381 @default.
• W2126231439 cites W1579992296 @default.
• W2126231439 cites W1599446163 @default.
• W2126231439 cites W1602308712 @default.
• W2126231439 cites W1621930152 @default.
• W2126231439 cites W1669071808 @default.
• W2126231439 cites W1939948552 @default.
• W2126231439 cites W1970613983 @default.
• W2126231439 cites W1982732431 @default.
• W2126231439 cites W2002025628 @default.
• W2126231439 cites W2010107901 @default.
• W2126231439 cites W2018226461 @default.
• W2126231439 cites W2023128306 @default.
• W2126231439 cites W2036049710 @default.
• W2126231439 cites W2038370680 @default.
• W2126231439 cites W2039933988 @default.
• W2126231439 cites W2040463645 @default.
• W2126231439 cites W2041504555 @default.
• W2126231439 cites W2048597976 @default.
• W2126231439 cites W2054480606 @default.
• W2126231439 cites W2056362812 @default.
• W2126231439 cites W2063449818 @default.
• W2126231439 cites W2064454347 @default.
• W2126231439 cites W2084532148 @default.
• W2126231439 cites W2092810452 @default.
• W2126231439 cites W2094319340 @default.
• W2126231439 cites W2108589013 @default.
• W2126231439 cites W2111112465 @default.
• W2126231439 cites W2121610160 @default.
• W2126231439 cites W2124587209 @default.
• W2126231439 cites W2125843236 @default.
• W2126231439 cites W2137006641 @default.
• W2126231439 cites W2148919096 @default.
• W2126231439 cites W2149777963 @default.
• W2126231439 cites W2155186392 @default.
• W2126231439 cites W2158134039 @default.
• W2126231439 cites W2158155888 @default.
• W2126231439 cites W2263138860 @default.
• W2126231439 cites W2319699534 @default.
• W2126231439 cites W2339491946 @default.
• W2126231439 cites W2415148390 @default.
• W2126231439 cites W4241419271 @default.
• W2126231439 cites W4313376846 @default.
• W2126231439 doi "https://doi.org/10.4049/jimmunol.175.10.6741" @default.
• W2126231439 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16272330" @default.
• W2126231439 hasPublicationYear "2005" @default.
• W2126231439 type Work @default.
• W2126231439 sameAs 2126231439 @default.
• W2126231439 citedByCount "15" @default.
• W2126231439 countsByYear W21262314392012 @default.
• W2126231439 countsByYear W21262314392013 @default.
• W2126231439 countsByYear W21262314392015 @default.
• W2126231439 countsByYear W21262314392017 @default.
• W2126231439 crossrefType "journal-article" @default.
• W2126231439 hasAuthorship W2126231439A5001206797 @default.
• W2126231439 hasAuthorship W2126231439A5002646374 @default.
• W2126231439 hasAuthorship W2126231439A5031321349 @default.
• W2126231439 hasAuthorship W2126231439A5034851812 @default.
• W2126231439 hasAuthorship W2126231439A5054587936 @default.
• W2126231439 hasAuthorship W2126231439A5056091318 @default.
• W2126231439 hasAuthorship W2126231439A5057957787 @default.
• W2126231439 hasAuthorship W2126231439A5058553369 @default.
• W2126231439 hasBestOaLocation W21262314391 @default.
• W2126231439 hasConcept C161478664 @default.
• W2126231439 hasConcept C181199279 @default.
• W2126231439 hasConcept C2776306059 @default.
• W2126231439 hasConcept C2776551241 @default.
• W2126231439 hasConcept C2776888444 @default.
• W2126231439 hasConcept C2776962512 @default.
• W2126231439 hasConcept C2778078955 @default.
• W2126231439 hasConcept C501593827 @default.
• W2126231439 hasConcept C55493867 @default.
• W2126231439 hasConcept C79879829 @default.
• W2126231439 hasConcept C86803240 @default.
• W2126231439 hasConcept C89423630 @default.
• W2126231439 hasConcept C98274493 @default.
• W2126231439 hasConcept C98539663 @default.
• W2126231439 hasConceptScore W2126231439C161478664 @default.
• W2126231439 hasConceptScore W2126231439C181199279 @default.
• W2126231439 hasConceptScore W2126231439C2776306059 @default.
• W2126231439 hasConceptScore W2126231439C2776551241 @default.
• W2126231439 hasConceptScore W2126231439C2776888444 @default.
• W2126231439 hasConceptScore W2126231439C2776962512 @default.
• W2126231439 hasConceptScore W2126231439C2778078955 @default.

• next