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• W2126242010 endingPage "1313" @default.
• W2126242010 startingPage "1294" @default.
• W2126242010 abstract "Abstract Cerebellar function is regulated by cholinergic mossy fiber inputs that are primarily derived from the medial vestibular nucleus ( MVN ) and prepositus hypoglossi nucleus ( PHN ). In contrast to the growing evidence surrounding cholinergic transmission and its functional significance in the cerebellum, the intrinsic and synaptic properties of cholinergic projection neurons ( C h PN s) have not been clarified. In this study, we generated choline acetyltransferase ( C h AT )‐td T omato transgenic rats, which specifically express the fluorescent protein td T omato in cholinergic neurons, and used them to investigate the response properties of C h PN s identified via retrograde labeling using whole‐cell recordings in brainstem slices. In response to current pulses, C h PN s exhibited two afterhyperpolarisation ( AHP ) profiles and three firing patterns; the predominant AHP and firing properties differed between the MVN and PHN . Morphologically, the C h PN s were separated into two types based on their soma size and dendritic extensions. Analyses of the firing responses to time‐varying sinusoidal current stimuli revealed that C h PN s exhibited different firing modes depending on the input frequencies. The maximum frequencies in which each firing mode was observed were different between the neurons that exhibited distinct firing patterns. Analyses of the current responses to the application of neurotransmitter receptor agonists revealed that the C h PN s expressed (i) AMPA ‐ and NMDA ‐type glutamate receptors, (ii) GABA A and glycine receptors, and (iii) muscarinic and nicotinic acetylcholine receptors. The current responses mediated by these receptors of MVN C h PN s were not different from those of PHN C h PN s. These findings suggest that C h PN s receive various synaptic inputs and encode those inputs appropriately across different frequencies." @default.
• W2126242010 created "2016-06-24" @default.
• W2126242010 creator A5010776860 @default.
• W2126242010 creator A5014321400 @default.
• W2126242010 creator A5043840252 @default.
• W2126242010 creator A5053556602 @default.
• W2126242010 date "2014-03-05" @default.
• W2126242010 modified "2023-10-04" @default.
• W2126242010 title "The vestibulo- and preposito-cerebellar cholinergic neurons of a ChAT-tdTomato transgenic rat exhibit heterogeneous firing properties and the expression of various neurotransmitter receptors" @default.
• W2126242010 cites W128738002 @default.
• W2126242010 cites W1627056129 @default.
• W2126242010 cites W1751127863 @default.
• W2126242010 cites W1879183682 @default.
• W2126242010 cites W1908651373 @default.
• W2126242010 cites W191828840 @default.
• W2126242010 cites W1918766900 @default.
• W2126242010 cites W1965770166 @default.
• W2126242010 cites W1966004596 @default.
• W2126242010 cites W1973378025 @default.
• W2126242010 cites W1974976117 @default.
• W2126242010 cites W1977015904 @default.
• W2126242010 cites W1977326232 @default.
• W2126242010 cites W1978488098 @default.
• W2126242010 cites W1985380927 @default.
• W2126242010 cites W1987364402 @default.
• W2126242010 cites W1988983700 @default.
• W2126242010 cites W1995094914 @default.
• W2126242010 cites W1997590875 @default.
• W2126242010 cites W2002197406 @default.
• W2126242010 cites W2002250549 @default.
• W2126242010 cites W2003312384 @default.
• W2126242010 cites W2003403547 @default.
• W2126242010 cites W2004589547 @default.
• W2126242010 cites W2005962773 @default.
• W2126242010 cites W2006605319 @default.
• W2126242010 cites W2008205503 @default.
• W2126242010 cites W2008787722 @default.
• W2126242010 cites W2010577665 @default.
• W2126242010 cites W2011437858 @default.
• W2126242010 cites W2014604103 @default.
• W2126242010 cites W2014725799 @default.
• W2126242010 cites W2015650507 @default.
• W2126242010 cites W2022035398 @default.
• W2126242010 cites W2022567711 @default.
• W2126242010 cites W2023421638 @default.
• W2126242010 cites W2030345831 @default.
• W2126242010 cites W2032430347 @default.
• W2126242010 cites W2033042583 @default.
• W2126242010 cites W2038043198 @default.
• W2126242010 cites W2039550248 @default.
• W2126242010 cites W2039734790 @default.
• W2126242010 cites W2042394625 @default.
• W2126242010 cites W2045198510 @default.
• W2126242010 cites W2045506744 @default.
• W2126242010 cites W2046466208 @default.
• W2126242010 cites W2047766053 @default.
• W2126242010 cites W2048770525 @default.
• W2126242010 cites W2051084778 @default.
• W2126242010 cites W2057917909 @default.
• W2126242010 cites W2065552223 @default.
• W2126242010 cites W2072486199 @default.
• W2126242010 cites W2075244325 @default.
• W2126242010 cites W2075855042 @default.
• W2126242010 cites W2082198705 @default.
• W2126242010 cites W2082769538 @default.
• W2126242010 cites W2088092784 @default.
• W2126242010 cites W2088576296 @default.
• W2126242010 cites W2089663252 @default.
• W2126242010 cites W2090591578 @default.
• W2126242010 cites W2090872672 @default.
• W2126242010 cites W2091470524 @default.
• W2126242010 cites W2093184684 @default.
• W2126242010 cites W2094317402 @default.
• W2126242010 cites W2094927194 @default.
• W2126242010 cites W2098799659 @default.
• W2126242010 cites W2112982765 @default.
• W2126242010 cites W2115734610 @default.
• W2126242010 cites W2121466553 @default.
• W2126242010 cites W2123072614 @default.
• W2126242010 cites W2131500354 @default.
• W2126242010 cites W2133003390 @default.
• W2126242010 cites W2145979004 @default.
• W2126242010 cites W2148990678 @default.
• W2126242010 cites W2154636938 @default.
• W2126242010 cites W2160525542 @default.
• W2126242010 cites W2162679150 @default.
• W2126242010 cites W2166419272 @default.
• W2126242010 cites W2167228285 @default.
• W2126242010 cites W2168579181 @default.
• W2126242010 cites W2340777212 @default.
• W2126242010 cites W3529170 @default.
• W2126242010 cites W4238271489 @default.
• W2126242010 cites W77026836 @default.
• W2126242010 doi "https://doi.org/10.1111/ejn.12509" @default.
• W2126242010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24593297" @default.
• W2126242010 hasPublicationYear "2014" @default.
• W2126242010 type Work @default.
• W2126242010 sameAs 2126242010 @default.

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