FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2126245225> ?p ?o ?g. }

• W2126245225 abstract "An increasing body of evidence now implicates acetaldehyde as a major underlying factor for the carcinogenicity of alcoholic beverages and especially for oesophageal and oral cancer. Acetaldehyde associated with alcohol consumption is regarded as 'carcinogenic to humans' (IARC Group 1), with sufficient evidence available for the oesophagus, head and neck as sites of carcinogenicity. At present, research into the mechanistic aspects of acetaldehyde-related oral cancer has been focused on salivary acetaldehyde that is formed either from ethanol metabolism in the epithelia or from microbial oxidation of ethanol by the oral microflora. This study was conducted to evaluate the role of the acetaldehyde that is found as a component of alcoholic beverages as an additional factor in the aetiology of oral cancer. Salivary acetaldehyde levels were determined in the context of sensory analysis of different alcoholic beverages (beer, cider, wine, sherry, vodka, calvados, grape marc spirit, tequila, cherry spirit), without swallowing, to exclude systemic ethanol metabolism. The rinsing of the mouth for 30 seconds with an alcoholic beverage is able to increase salivary acetaldehyde above levels previously judged to be carcinogenic in vitro, with levels up to 1000 μM in cases of beverages with extreme acetaldehyde content. In general, the highest salivary acetaldehyde concentration was found in all cases in the saliva 30 sec after using the beverages (average 353 μM). The average concentration then decreased at the 2-min (156 μM), 5-min (76 μM) and 10-min (40 μM) sampling points. The salivary acetaldehyde concentration depends primarily on the direct ingestion of acetaldehyde contained in the beverages at the 30-sec sampling, while the influence of the metabolic formation from ethanol becomes the major factor at the 2-min sampling point. This study offers a plausible mechanism to explain the increased risk for oral cancer associated with high acetaldehyde concentrations in certain beverages." @default.
• W2126245225 created "2016-06-24" @default.
• W2126245225 creator A5017883916 @default.
• W2126245225 creator A5019607152 @default.
• W2126245225 date "2011-01-06" @default.
• W2126245225 modified "2023-10-12" @default.
• W2126245225 title "Short-term salivary acetaldehyde increase due to direct exposure to alcoholic beverages as an additional cancer risk factor beyond ethanol metabolism" @default.
• W2126245225 cites W1680938096 @default.
• W2126245225 cites W1969016723 @default.
• W2126245225 cites W1972861393 @default.
• W2126245225 cites W1990918187 @default.
• W2126245225 cites W1998531204 @default.
• W2126245225 cites W1999641310 @default.
• W2126245225 cites W2000064888 @default.
• W2126245225 cites W2007734732 @default.
• W2126245225 cites W2013827205 @default.
• W2126245225 cites W2018135173 @default.
• W2126245225 cites W2026926750 @default.
• W2126245225 cites W2030968250 @default.
• W2126245225 cites W2037391975 @default.
• W2126245225 cites W2039506101 @default.
• W2126245225 cites W2046280583 @default.
• W2126245225 cites W2047535989 @default.
• W2126245225 cites W2048244745 @default.
• W2126245225 cites W2050503768 @default.
• W2126245225 cites W2051208083 @default.
• W2126245225 cites W2052640269 @default.
• W2126245225 cites W2053012139 @default.
• W2126245225 cites W2056356075 @default.
• W2126245225 cites W2056887602 @default.
• W2126245225 cites W2057201155 @default.
• W2126245225 cites W2061766961 @default.
• W2126245225 cites W2076346268 @default.
• W2126245225 cites W2080812486 @default.
• W2126245225 cites W2086758182 @default.
• W2126245225 cites W2088568178 @default.
• W2126245225 cites W2091841604 @default.
• W2126245225 cites W2114924136 @default.
• W2126245225 cites W2120244810 @default.
• W2126245225 cites W2127744865 @default.
• W2126245225 cites W2128340087 @default.
• W2126245225 cites W2130785878 @default.
• W2126245225 cites W2131940308 @default.
• W2126245225 cites W2142965797 @default.
• W2126245225 cites W2143170156 @default.
• W2126245225 cites W2144635719 @default.
• W2126245225 cites W2150978557 @default.
• W2126245225 cites W2155827262 @default.
• W2126245225 cites W2159657105 @default.
• W2126245225 cites W2160914180 @default.
• W2126245225 cites W2163081580 @default.
• W2126245225 cites W2171038136 @default.
• W2126245225 cites W2171106600 @default.
• W2126245225 cites W2252395662 @default.
• W2126245225 cites W231385219 @default.
• W2126245225 cites W268934328 @default.
• W2126245225 doi "https://doi.org/10.1186/1756-9966-30-3" @default.
• W2126245225 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3022748" @default.
• W2126245225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21211027" @default.
• W2126245225 hasPublicationYear "2011" @default.
• W2126245225 type Work @default.
• W2126245225 sameAs 2126245225 @default.
• W2126245225 citedByCount "55" @default.
• W2126245225 countsByYear W21262452252012 @default.
• W2126245225 countsByYear W21262452252013 @default.
• W2126245225 countsByYear W21262452252014 @default.
• W2126245225 countsByYear W21262452252015 @default.
• W2126245225 countsByYear W21262452252016 @default.
• W2126245225 countsByYear W21262452252017 @default.
• W2126245225 countsByYear W21262452252018 @default.
• W2126245225 countsByYear W21262452252020 @default.
• W2126245225 countsByYear W21262452252021 @default.
• W2126245225 countsByYear W21262452252022 @default.
• W2126245225 countsByYear W21262452252023 @default.
• W2126245225 crossrefType "journal-article" @default.
• W2126245225 hasAuthorship W2126245225A5017883916 @default.
• W2126245225 hasAuthorship W2126245225A5019607152 @default.
• W2126245225 hasBestOaLocation W21262452251 @default.
• W2126245225 hasConcept C104317684 @default.
• W2126245225 hasConcept C114246631 @default.
• W2126245225 hasConcept C121608353 @default.
• W2126245225 hasConcept C126322002 @default.
• W2126245225 hasConcept C185592680 @default.
• W2126245225 hasConcept C193230392 @default.
• W2126245225 hasConcept C25747580 @default.
• W2126245225 hasConcept C2777595113 @default.
• W2126245225 hasConcept C2780161600 @default.
• W2126245225 hasConcept C2781066024 @default.
• W2126245225 hasConcept C30153976 @default.
• W2126245225 hasConcept C3175096 @default.
• W2126245225 hasConcept C31903555 @default.
• W2126245225 hasConcept C504460877 @default.
• W2126245225 hasConcept C55493867 @default.
• W2126245225 hasConcept C55952523 @default.
• W2126245225 hasConcept C71924100 @default.
• W2126245225 hasConceptScore W2126245225C104317684 @default.
• W2126245225 hasConceptScore W2126245225C114246631 @default.
• W2126245225 hasConceptScore W2126245225C121608353 @default.
• W2126245225 hasConceptScore W2126245225C126322002 @default.
• W2126245225 hasConceptScore W2126245225C185592680 @default.

• next