FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2126248220> ?p ?o ?g. }

• W2126248220 endingPage "2623" @default.
• W2126248220 startingPage "2612" @default.
• W2126248220 abstract "ABSTRACT Listeria monocytogenes is an intracellular bacterial pathogen whose virulence depends on the regulated expression of numerous secreted bacterial factors. As for other gram-positive bacteria, many proteins secreted by L. monocytogenes are translocated across the bacterial membrane in an unfolded state to the compartment existing between the membrane and the cell wall. This compartment presents a challenging environment for protein folding due to its high density of negative charge, high concentrations of cations, and low pH. We recently identified PrsA2 as a gene product required for L. monocytogenes virulence. PrsA2 was identified based on its increased secretion by strains containing a mutationally activated form of prfA , the key regulator of L. monocytogenes virulence gene expression. The prsA2 gene product is one of at least two predicted peptidyl-prolyl cis / trans -isomerases encoded by L. monocytogenes ; these proteins function as posttranslocation protein chaperones and/or foldases. In this study, we demonstrate that PrsA2 plays a unique and important role in L. monocytogenes pathogenesis by promoting the activity and stability of at least two critical secreted virulence factors: listeriolysin O (LLO) and a broad-specificity phospholipase. Loss of PrsA2 activity severely attenuated virulence in mice and impaired bacterial cell-to-cell spread in host cells. In contrast, mutants lacking prsA1 resembled wild-type bacteria with respect to intracellular growth and cell-to-cell spread as well as virulence in mice. PrsA2 is thus distinct from PrsA1 in its unique requirement for the stability and full activity of L. monocytogenes -secreted factors that contribute to host infection." @default.
• W2126248220 created "2016-06-24" @default.
• W2126248220 creator A5031654301 @default.
• W2126248220 creator A5058791363 @default.
• W2126248220 creator A5068870381 @default.
• W2126248220 creator A5081498195 @default.
• W2126248220 date "2009-07-01" @default.
• W2126248220 modified "2023-10-11" @default.
• W2126248220 title "The Posttranslocation Chaperone PrsA2 Contributes to Multiple Facets of<i>Listeria monocytogenes</i>Pathogenesis" @default.
• W2126248220 cites W1487973635 @default.
• W2126248220 cites W1504183214 @default.
• W2126248220 cites W155617828 @default.
• W2126248220 cites W1827581926 @default.
• W2126248220 cites W1850330698 @default.
• W2126248220 cites W1909750055 @default.
• W2126248220 cites W1937850854 @default.
• W2126248220 cites W1965892962 @default.
• W2126248220 cites W1967475000 @default.
• W2126248220 cites W1968477104 @default.
• W2126248220 cites W1983717852 @default.
• W2126248220 cites W1983987888 @default.
• W2126248220 cites W1985346180 @default.
• W2126248220 cites W1992044657 @default.
• W2126248220 cites W1993802761 @default.
• W2126248220 cites W2000106054 @default.
• W2126248220 cites W2005476432 @default.
• W2126248220 cites W2011593106 @default.
• W2126248220 cites W2035752210 @default.
• W2126248220 cites W2041183732 @default.
• W2126248220 cites W2043961065 @default.
• W2126248220 cites W2047069686 @default.
• W2126248220 cites W2048362584 @default.
• W2126248220 cites W2055351624 @default.
• W2126248220 cites W2056955163 @default.
• W2126248220 cites W2058522812 @default.
• W2126248220 cites W2059206113 @default.
• W2126248220 cites W2063411991 @default.
• W2126248220 cites W2065390599 @default.
• W2126248220 cites W2072835084 @default.
• W2126248220 cites W2076198022 @default.
• W2126248220 cites W2082250039 @default.
• W2126248220 cites W2086345249 @default.
• W2126248220 cites W2088966542 @default.
• W2126248220 cites W2091799286 @default.
• W2126248220 cites W2093417734 @default.
• W2126248220 cites W2094070743 @default.
• W2126248220 cites W2094304821 @default.
• W2126248220 cites W2095655760 @default.
• W2126248220 cites W2097294790 @default.
• W2126248220 cites W2101944658 @default.
• W2126248220 cites W2103773798 @default.
• W2126248220 cites W2106962230 @default.
• W2126248220 cites W2110848767 @default.
• W2126248220 cites W2111023392 @default.
• W2126248220 cites W2111310696 @default.
• W2126248220 cites W2116050121 @default.
• W2126248220 cites W2122857784 @default.
• W2126248220 cites W2122862437 @default.
• W2126248220 cites W2124712142 @default.
• W2126248220 cites W2126569085 @default.
• W2126248220 cites W2128302846 @default.
• W2126248220 cites W2129937025 @default.
• W2126248220 cites W2130487625 @default.
• W2126248220 cites W2132096157 @default.
• W2126248220 cites W2132536095 @default.
• W2126248220 cites W2133817650 @default.
• W2126248220 cites W2134076858 @default.
• W2126248220 cites W2137571507 @default.
• W2126248220 cites W2138461159 @default.
• W2126248220 cites W2140028577 @default.
• W2126248220 cites W2143001577 @default.
• W2126248220 cites W2144014651 @default.
• W2126248220 cites W2147395065 @default.
• W2126248220 cites W2148537117 @default.
• W2126248220 cites W2151905290 @default.
• W2126248220 cites W2155180509 @default.
• W2126248220 cites W2155183797 @default.
• W2126248220 cites W2155975415 @default.
• W2126248220 cites W2157249590 @default.
• W2126248220 cites W2159088387 @default.
• W2126248220 cites W2159607253 @default.
• W2126248220 cites W2159650159 @default.
• W2126248220 cites W2159698005 @default.
• W2126248220 cites W2160318665 @default.
• W2126248220 cites W2160473051 @default.
• W2126248220 cites W2161646716 @default.
• W2126248220 cites W2164276385 @default.
• W2126248220 cites W2170906273 @default.
• W2126248220 cites W2172259963 @default.
• W2126248220 cites W2236777032 @default.
• W2126248220 doi "https://doi.org/10.1128/iai.00280-09" @default.
• W2126248220 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2708592" @default.
• W2126248220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19451247" @default.
• W2126248220 hasPublicationYear "2009" @default.
• W2126248220 type Work @default.
• W2126248220 sameAs 2126248220 @default.
• W2126248220 citedByCount "56" @default.
• W2126248220 countsByYear W21262482202012 @default.

• next