Matches in SemOpenAlex for { <https://semopenalex.org/work/W2126255798> ?p ?o ?g. }
- W2126255798 endingPage "77" @default.
- W2126255798 startingPage "69" @default.
- W2126255798 abstract "G protein-coupled receptor 35 (GPR35) has been characterized to be one of the genes that are up-regulated in human heart failure. Since mechanisms controlling GPR35 expression are not known, we investigated the regulation of GPR35 gene and protein expression in cardiac myocytes and in the mouse models of cardiac failure.In cardiac myocytes, GPR35 gene expression was found to be exceptionally sensitive to hypoxia and induced by hypoxia-inducible factor-1 (HIF-1) activation. HIF-1-dependent regulation was established by genetic (HIF-1/VP16, Inhibitory Per/Arnt/Sim domain protein) and chemical [desferrioxamine (DFO)] modulation of the HIF-1 pathway and further confirmed by mutation analysis of the GPR35 promoter and by demonstrating direct binding of endogenous HIF-1 to the gene promoter. Hypoxia increased the number and density of GPR35 receptors on the cardiomyocyte cell membranes. Chemical GPR35 agonist Zaprinast caused GPR35 activation and receptor internalization in cardiac myocytes. In addition, overexpressed GPR35 disrupted actin cytoskeleton arrangement and caused morphological changes in cultured cardiomyocytes. GPR35 gene and protein expressions were also induced in mouse models of cardiac failure; the acute phase of myocardial infarction and during the compensatory and decompensatory phase of pressure-load induced cardiac hypertrophy.Cardiac expression of GPR35 is regulated by hypoxia through activation of HIF-1. The expression of GPR35 in mouse models of cardiac infarction and pressure load suggests that GPR35 could be used as an early marker of progressive cardiac failure." @default.
- W2126255798 created "2016-06-24" @default.
- W2126255798 creator A5007817118 @default.
- W2126255798 creator A5014220812 @default.
- W2126255798 creator A5018593288 @default.
- W2126255798 creator A5026566745 @default.
- W2126255798 creator A5050772170 @default.
- W2126255798 creator A5076413802 @default.
- W2126255798 creator A5080760539 @default.
- W2126255798 creator A5081578056 @default.
- W2126255798 creator A5089068068 @default.
- W2126255798 date "2013-10-04" @default.
- W2126255798 modified "2023-10-17" @default.
- W2126255798 title "Hypoxia-inducible factor 1-induced G protein-coupled receptor 35 expression is an early marker of progressive cardiac remodelling" @default.
- W2126255798 cites W1496442060 @default.
- W2126255798 cites W1937401270 @default.
- W2126255798 cites W1968001320 @default.
- W2126255798 cites W1984584304 @default.
- W2126255798 cites W1989063086 @default.
- W2126255798 cites W1991286144 @default.
- W2126255798 cites W1994446230 @default.
- W2126255798 cites W1996095240 @default.
- W2126255798 cites W2000804199 @default.
- W2126255798 cites W2002199803 @default.
- W2126255798 cites W2003767769 @default.
- W2126255798 cites W2019922945 @default.
- W2126255798 cites W2025609751 @default.
- W2126255798 cites W2035968282 @default.
- W2126255798 cites W2047638715 @default.
- W2126255798 cites W2065156829 @default.
- W2126255798 cites W2072708194 @default.
- W2126255798 cites W2072727898 @default.
- W2126255798 cites W2074259147 @default.
- W2126255798 cites W2075639694 @default.
- W2126255798 cites W2077537799 @default.
- W2126255798 cites W2081184877 @default.
- W2126255798 cites W2083743528 @default.
- W2126255798 cites W2091196189 @default.
- W2126255798 cites W2112494390 @default.
- W2126255798 cites W2114364250 @default.
- W2126255798 cites W2115774517 @default.
- W2126255798 cites W2129915053 @default.
- W2126255798 cites W2132461193 @default.
- W2126255798 cites W2134956208 @default.
- W2126255798 cites W2167487237 @default.
- W2126255798 cites W2171108415 @default.
- W2126255798 doi "https://doi.org/10.1093/cvr/cvt226" @default.
- W2126255798 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24095869" @default.
- W2126255798 hasPublicationYear "2013" @default.
- W2126255798 type Work @default.
- W2126255798 sameAs 2126255798 @default.
- W2126255798 citedByCount "38" @default.
- W2126255798 countsByYear W21262557982014 @default.
- W2126255798 countsByYear W21262557982015 @default.
- W2126255798 countsByYear W21262557982016 @default.
- W2126255798 countsByYear W21262557982017 @default.
- W2126255798 countsByYear W21262557982018 @default.
- W2126255798 countsByYear W21262557982019 @default.
- W2126255798 countsByYear W21262557982020 @default.
- W2126255798 countsByYear W21262557982021 @default.
- W2126255798 countsByYear W21262557982022 @default.
- W2126255798 countsByYear W21262557982023 @default.
- W2126255798 crossrefType "journal-article" @default.
- W2126255798 hasAuthorship W2126255798A5007817118 @default.
- W2126255798 hasAuthorship W2126255798A5014220812 @default.
- W2126255798 hasAuthorship W2126255798A5018593288 @default.
- W2126255798 hasAuthorship W2126255798A5026566745 @default.
- W2126255798 hasAuthorship W2126255798A5050772170 @default.
- W2126255798 hasAuthorship W2126255798A5076413802 @default.
- W2126255798 hasAuthorship W2126255798A5080760539 @default.
- W2126255798 hasAuthorship W2126255798A5081578056 @default.
- W2126255798 hasAuthorship W2126255798A5089068068 @default.
- W2126255798 hasBestOaLocation W21262557981 @default.
- W2126255798 hasConcept C104317684 @default.
- W2126255798 hasConcept C150194340 @default.
- W2126255798 hasConcept C153911025 @default.
- W2126255798 hasConcept C207200792 @default.
- W2126255798 hasConcept C55493867 @default.
- W2126255798 hasConcept C86803240 @default.
- W2126255798 hasConcept C95444343 @default.
- W2126255798 hasConceptScore W2126255798C104317684 @default.
- W2126255798 hasConceptScore W2126255798C150194340 @default.
- W2126255798 hasConceptScore W2126255798C153911025 @default.
- W2126255798 hasConceptScore W2126255798C207200792 @default.
- W2126255798 hasConceptScore W2126255798C55493867 @default.
- W2126255798 hasConceptScore W2126255798C86803240 @default.
- W2126255798 hasConceptScore W2126255798C95444343 @default.
- W2126255798 hasIssue "1" @default.
- W2126255798 hasLocation W21262557981 @default.
- W2126255798 hasLocation W21262557982 @default.
- W2126255798 hasOpenAccess W2126255798 @default.
- W2126255798 hasPrimaryLocation W21262557981 @default.
- W2126255798 hasRelatedWork W2009966535 @default.
- W2126255798 hasRelatedWork W2013966206 @default.
- W2126255798 hasRelatedWork W2049475166 @default.
- W2126255798 hasRelatedWork W2077423437 @default.
- W2126255798 hasRelatedWork W2134183508 @default.
- W2126255798 hasRelatedWork W2200545821 @default.