FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2126262308> ?p ?o ?g. }

• W2126262308 abstract "Permanent focal brain damage can have critical effects on the function of nearby as well as remote brain regions. However, the effects of transient disturbances on global brain function are largely unknown. Our goal was to develop an experimental in vivo model to map the impact of transient functional brain impairment on large-scale neural networks in the absence of structural damage. We describe a new rat model of transient functional hemispheric disruption using unilateral focal anesthesia by intracarotid pentobarbital injection. The brain's functional status was assessed with resting-state fMRI (rs-fMRI) and electroencephalography (EEG). We performed network analysis to identify and quantify highly connected network hubs, i.e., rich-club organization, in pre- and postbarbital functional networks. Perfusion MRI data demonstrated that the catheterized carotid artery predominantly supplied the ipsilateral hemisphere, allowing for selective hemispheric brain silencing. The prebarbital baseline network displayed strong functional connectivity (FC) within and between hemispheres. Following pentobarbital injection, the disrupted hemisphere revealed increased intrahemispheric FC with concomitant decrease of interhemispheric connectivity. The bilateral functional network was characterized by a strong positive rich-club effect, which was not affected by ipsilateral disruption. Nevertheless, the rich-club value was significantly decreased in the ipsilateral hemisphere and to a lesser extent contralaterally. Loss of interhemispheric EEG synchronization supported the rs-fMRI findings. Our data support the concept that densely connected rich-club regions play a central role in global brain communication, and show that network hub configurations can be significantly affected by focal temporary functional hemispheric disruption without structural neuronal damage. Further studies with this rat model will provide essential additional insights into network reorganization patterns in response to transient functional brain disruption." @default.
• W2126262308 created "2016-06-24" @default.
• W2126262308 creator A5013830811 @default.
• W2126262308 creator A5031300516 @default.
• W2126262308 creator A5064705806 @default.
• W2126262308 creator A5075016511 @default.
• W2126262308 date "2014-03-21" @default.
• W2126262308 modified "2023-10-06" @default.
• W2126262308 title "Effects of transient unilateral functional brain disruption on global neural network status in rats: a methods paper" @default.
• W2126262308 cites W1976197861 @default.
• W2126262308 cites W1983485726 @default.
• W2126262308 cites W1984988256 @default.
• W2126262308 cites W1985673618 @default.
• W2126262308 cites W1986818175 @default.
• W2126262308 cites W1990574575 @default.
• W2126262308 cites W1993785630 @default.
• W2126262308 cites W1996186792 @default.
• W2126262308 cites W2012559638 @default.
• W2126262308 cites W2013822553 @default.
• W2126262308 cites W2014006430 @default.
• W2126262308 cites W2015334431 @default.
• W2126262308 cites W2044118104 @default.
• W2126262308 cites W2046246518 @default.
• W2126262308 cites W2049745117 @default.
• W2126262308 cites W2099875458 @default.
• W2126262308 cites W2105824687 @default.
• W2126262308 cites W2108990419 @default.
• W2126262308 cites W2115138492 @default.
• W2126262308 cites W2131181615 @default.
• W2126262308 cites W2136404265 @default.
• W2126262308 cites W2138990725 @default.
• W2126262308 cites W2143348404 @default.
• W2126262308 cites W2145979322 @default.
• W2126262308 cites W2146406922 @default.
• W2126262308 cites W2149055390 @default.
• W2126262308 cites W2152575270 @default.
• W2126262308 cites W2159929956 @default.
• W2126262308 cites W2162771038 @default.
• W2126262308 cites W2166905390 @default.
• W2126262308 cites W2167822639 @default.
• W2126262308 cites W2169876532 @default.
• W2126262308 doi "https://doi.org/10.3389/fnsys.2014.00040" @default.
• W2126262308 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3968768" @default.
• W2126262308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24711789" @default.
• W2126262308 hasPublicationYear "2014" @default.
• W2126262308 type Work @default.
• W2126262308 sameAs 2126262308 @default.
• W2126262308 citedByCount "4" @default.
• W2126262308 countsByYear W21262623082015 @default.
• W2126262308 countsByYear W21262623082017 @default.
• W2126262308 countsByYear W21262623082020 @default.
• W2126262308 crossrefType "journal-article" @default.
• W2126262308 hasAuthorship W2126262308A5013830811 @default.
• W2126262308 hasAuthorship W2126262308A5031300516 @default.
• W2126262308 hasAuthorship W2126262308A5064705806 @default.
• W2126262308 hasAuthorship W2126262308A5075016511 @default.
• W2126262308 hasBestOaLocation W21262623081 @default.
• W2126262308 hasConcept C15744967 @default.
• W2126262308 hasConcept C169760540 @default.
• W2126262308 hasConcept C3018011982 @default.
• W2126262308 hasConcept C522805319 @default.
• W2126262308 hasConcept C66324658 @default.
• W2126262308 hasConcept C79840881 @default.
• W2126262308 hasConceptScore W2126262308C15744967 @default.
• W2126262308 hasConceptScore W2126262308C169760540 @default.
• W2126262308 hasConceptScore W2126262308C3018011982 @default.
• W2126262308 hasConceptScore W2126262308C522805319 @default.
• W2126262308 hasConceptScore W2126262308C66324658 @default.
• W2126262308 hasConceptScore W2126262308C79840881 @default.
• W2126262308 hasLocation W21262623081 @default.
• W2126262308 hasLocation W21262623082 @default.
• W2126262308 hasLocation W21262623083 @default.
• W2126262308 hasLocation W21262623084 @default.
• W2126262308 hasLocation W21262623085 @default.
• W2126262308 hasOpenAccess W2126262308 @default.
• W2126262308 hasPrimaryLocation W21262623081 @default.
• W2126262308 hasRelatedWork W1520477417 @default.
• W2126262308 hasRelatedWork W2134927621 @default.
• W2126262308 hasRelatedWork W2148334755 @default.
• W2126262308 hasRelatedWork W2283746446 @default.
• W2126262308 hasRelatedWork W2945168867 @default.
• W2126262308 hasRelatedWork W3016599742 @default.
• W2126262308 hasRelatedWork W3017098243 @default.
• W2126262308 hasRelatedWork W3150454329 @default.
• W2126262308 hasRelatedWork W4229855818 @default.
• W2126262308 hasRelatedWork W4232465970 @default.
• W2126262308 hasVolume "8" @default.
• W2126262308 isParatext "false" @default.
• W2126262308 isRetracted "false" @default.
• W2126262308 magId "2126262308" @default.
• W2126262308 workType "article" @default.