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- W2126268972 endingPage "249" @default.
- W2126268972 startingPage "229" @default.
- W2126268972 abstract "Pancreatitis is caused by inflammatory injury to the exocrine pancreas, from which both humans and animal models appear to recover via regeneration of digestive enzyme–producing acinar cells. This regenerative process involves transient phases of inflammation, metaplasia, and redifferentiation, driven by cell-cell interactions between acinar cells, leukocytes, and resident fibroblasts. The NFκB signaling pathway is a critical determinant of pancreatic inflammation and metaplasia, whereas a number of developmental signals and transcription factors are devoted to promoting acinar redifferentiation after injury. Imbalances between these proinflammatory and prodifferentiation pathways contribute to chronic pancreatitis, characterized by persistent inflammation, fibrosis, and acinar dedifferentiation. Loss of acinar cell differentiation also drives pancreatic cancer initiation, providing a mechanistic link between pancreatitis and cancer risk. Unraveling the molecular bases of exocrine regeneration may identify new therapeutic targets for treatment and prevention of both of these deadly diseases." @default.
- W2126268972 created "2016-06-24" @default.
- W2126268972 creator A5014316809 @default.
- W2126268972 creator A5080071044 @default.
- W2126268972 date "2015-02-10" @default.
- W2126268972 modified "2023-10-17" @default.
- W2126268972 title "Regeneration and Repair of the Exocrine Pancreas" @default.
- W2126268972 cites W1589311660 @default.
- W2126268972 cites W1603492810 @default.
- W2126268972 cites W1861220418 @default.
- W2126268972 cites W1964190813 @default.
- W2126268972 cites W1967081779 @default.
- W2126268972 cites W1969201526 @default.
- W2126268972 cites W1970539851 @default.
- W2126268972 cites W1973058645 @default.
- W2126268972 cites W1973758000 @default.
- W2126268972 cites W1977251457 @default.
- W2126268972 cites W1978148663 @default.
- W2126268972 cites W1979573066 @default.
- W2126268972 cites W1980657671 @default.
- W2126268972 cites W1981362835 @default.
- W2126268972 cites W1982307952 @default.
- W2126268972 cites W1983959103 @default.
- W2126268972 cites W1986382086 @default.
- W2126268972 cites W1986829345 @default.
- W2126268972 cites W1987220381 @default.
- W2126268972 cites W1988363662 @default.
- W2126268972 cites W1989732890 @default.
- W2126268972 cites W1990567821 @default.
- W2126268972 cites W1990826732 @default.
- W2126268972 cites W1990883760 @default.
- W2126268972 cites W1993164825 @default.
- W2126268972 cites W1993913862 @default.
- W2126268972 cites W1995243958 @default.
- W2126268972 cites W1996912024 @default.
- W2126268972 cites W1999202962 @default.
- W2126268972 cites W2000499773 @default.
- W2126268972 cites W2002228431 @default.
- W2126268972 cites W2002248601 @default.
- W2126268972 cites W2002267961 @default.
- W2126268972 cites W2006475805 @default.
- W2126268972 cites W2007433998 @default.
- W2126268972 cites W2009860586 @default.
- W2126268972 cites W2010184452 @default.
- W2126268972 cites W2011400811 @default.
- W2126268972 cites W2011710385 @default.
- W2126268972 cites W2019236383 @default.
- W2126268972 cites W2019384565 @default.
- W2126268972 cites W2021766591 @default.
- W2126268972 cites W2027161267 @default.
- W2126268972 cites W2032347026 @default.
- W2126268972 cites W2033548191 @default.
- W2126268972 cites W2033997896 @default.
- W2126268972 cites W2041739600 @default.
- W2126268972 cites W2053402030 @default.
- W2126268972 cites W2055007285 @default.
- W2126268972 cites W2056646351 @default.
- W2126268972 cites W2060082095 @default.
- W2126268972 cites W2068336702 @default.
- W2126268972 cites W2069366124 @default.
- W2126268972 cites W2069370434 @default.
- W2126268972 cites W2075712485 @default.
- W2126268972 cites W2080489534 @default.
- W2126268972 cites W2081263070 @default.
- W2126268972 cites W2081935849 @default.
- W2126268972 cites W2084089742 @default.
- W2126268972 cites W2084277057 @default.
- W2126268972 cites W2086555099 @default.
- W2126268972 cites W2087276195 @default.
- W2126268972 cites W2088110734 @default.
- W2126268972 cites W2089688272 @default.
- W2126268972 cites W2089784089 @default.
- W2126268972 cites W2090709209 @default.
- W2126268972 cites W2092607664 @default.
- W2126268972 cites W2092783134 @default.
- W2126268972 cites W2094602845 @default.
- W2126268972 cites W2095211207 @default.
- W2126268972 cites W2095940849 @default.
- W2126268972 cites W2096547892 @default.
- W2126268972 cites W2096692958 @default.
- W2126268972 cites W2097573911 @default.
- W2126268972 cites W2098511833 @default.
- W2126268972 cites W2098517576 @default.
- W2126268972 cites W2100034830 @default.
- W2126268972 cites W2101990128 @default.
- W2126268972 cites W2106597511 @default.
- W2126268972 cites W2107890914 @default.
- W2126268972 cites W2114371597 @default.
- W2126268972 cites W2116100337 @default.
- W2126268972 cites W2121139915 @default.
- W2126268972 cites W2123155461 @default.
- W2126268972 cites W2123852594 @default.
- W2126268972 cites W2124018740 @default.
- W2126268972 cites W2126780067 @default.
- W2126268972 cites W2129140055 @default.
- W2126268972 cites W2129740176 @default.
- W2126268972 cites W2130112621 @default.
- W2126268972 cites W2130251290 @default.