FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2126275910> ?p ?o ?g. }

• W2126275910 endingPage "3234" @default.
• W2126275910 startingPage "3226" @default.
• W2126275910 abstract "We investigated the link between cell movement and plasma membrane recycling using a fast-acting, temperature-sensitive mutant of the Dictyostelium SecA exocytic protein. Strikingly, most mutant cells become almost paralysed within minutes at the restrictive temperature. However, they can still sense cyclic-AMP (cAMP) gradients and polymerise actin up-gradient, but form only abortive pseudopodia, which cannot expand. They also relay a cAMP signal normally, suggesting that cAMP is released by a non-exocytic mechanism. To investigate why SecA is required for motility, we examined membrane trafficking in the mutant. Plasma membrane circulation is rapidly inhibited at the restrictive temperature and the cells acquire a prominent vesicle. Organelle-specific markers show that this is an undischarged contractile vacuole, and we found the cells are correspondingly osmo-sensitive. Electron microscopy shows that many smaller vesicles, probably originating from the plasma membrane, also accumulate at the restrictive temperature. Consistent with this, the surface area of mutant cells shrinks. We suggest that SecA mutant cells cannot move at the restrictive temperature because their block in exocytosis results in a net uptake of plasma membrane, reducing its area, and so restricting pseudopodial expansion. This demonstrates the importance of proper surface area regulation in cell movement." @default.
• W2126275910 created "2016-06-24" @default.
• W2126275910 creator A5041856919 @default.
• W2126275910 creator A5045772418 @default.
• W2126275910 creator A5061659558 @default.
• W2126275910 creator A5090977575 @default.
• W2126275910 date "2010-10-01" @default.
• W2126275910 modified "2023-09-27" @default.
• W2126275910 title "The exocytic gene<i>secA</i>is required for<i>Dictyostelium</i>cell motility and osmoregulation" @default.
• W2126275910 cites W1578383688 @default.
• W2126275910 cites W1886628176 @default.
• W2126275910 cites W1964441922 @default.
• W2126275910 cites W1965158583 @default.
• W2126275910 cites W1966073555 @default.
• W2126275910 cites W1979922171 @default.
• W2126275910 cites W1983272195 @default.
• W2126275910 cites W1984164971 @default.
• W2126275910 cites W1984289934 @default.
• W2126275910 cites W1988928395 @default.
• W2126275910 cites W1990827051 @default.
• W2126275910 cites W1993423963 @default.
• W2126275910 cites W1995051428 @default.
• W2126275910 cites W1996071174 @default.
• W2126275910 cites W1996121280 @default.
• W2126275910 cites W1996479070 @default.
• W2126275910 cites W2003650736 @default.
• W2126275910 cites W2004083309 @default.
• W2126275910 cites W2013451774 @default.
• W2126275910 cites W2013673237 @default.
• W2126275910 cites W2014672873 @default.
• W2126275910 cites W2021394111 @default.
• W2126275910 cites W2021460799 @default.
• W2126275910 cites W2022341198 @default.
• W2126275910 cites W2024136850 @default.
• W2126275910 cites W2027810833 @default.
• W2126275910 cites W2031183644 @default.
• W2126275910 cites W2031212561 @default.
• W2126275910 cites W2035538295 @default.
• W2126275910 cites W2045883887 @default.
• W2126275910 cites W2046643029 @default.
• W2126275910 cites W2053550995 @default.
• W2126275910 cites W205821215 @default.
• W2126275910 cites W2059775037 @default.
• W2126275910 cites W2061177016 @default.
• W2126275910 cites W2062191754 @default.
• W2126275910 cites W2066671220 @default.
• W2126275910 cites W2069695739 @default.
• W2126275910 cites W2077020319 @default.
• W2126275910 cites W2080658642 @default.
• W2126275910 cites W2098360662 @default.
• W2126275910 cites W2114850244 @default.
• W2126275910 cites W2114915892 @default.
• W2126275910 cites W2116365110 @default.
• W2126275910 cites W2121882207 @default.
• W2126275910 cites W2123729988 @default.
• W2126275910 cites W2133698151 @default.
• W2126275910 cites W2143408794 @default.
• W2126275910 cites W2148292818 @default.
• W2126275910 cites W2149323329 @default.
• W2126275910 cites W2151825535 @default.
• W2126275910 cites W2161309298 @default.
• W2126275910 cites W2164495477 @default.
• W2126275910 cites W2404782179 @default.
• W2126275910 cites W2416620668 @default.
• W2126275910 cites W2422015602 @default.
• W2126275910 cites W2742272146 @default.
• W2126275910 doi "https://doi.org/10.1242/jcs.072876" @default.
• W2126275910 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2939799" @default.
• W2126275910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20807800" @default.
• W2126275910 hasPublicationYear "2010" @default.
• W2126275910 type Work @default.
• W2126275910 sameAs 2126275910 @default.
• W2126275910 citedByCount "15" @default.
• W2126275910 countsByYear W21262759102012 @default.
• W2126275910 countsByYear W21262759102013 @default.
• W2126275910 countsByYear W21262759102014 @default.
• W2126275910 countsByYear W21262759102016 @default.
• W2126275910 countsByYear W21262759102017 @default.
• W2126275910 countsByYear W21262759102020 @default.
• W2126275910 countsByYear W21262759102022 @default.
• W2126275910 crossrefType "journal-article" @default.
• W2126275910 hasAuthorship W2126275910A5041856919 @default.
• W2126275910 hasAuthorship W2126275910A5045772418 @default.
• W2126275910 hasAuthorship W2126275910A5061659558 @default.
• W2126275910 hasAuthorship W2126275910A5090977575 @default.
• W2126275910 hasBestOaLocation W21262759102 @default.
• W2126275910 hasConcept C102568950 @default.
• W2126275910 hasConcept C104317684 @default.
• W2126275910 hasConcept C12554922 @default.
• W2126275910 hasConcept C125705527 @default.
• W2126275910 hasConcept C130316041 @default.
• W2126275910 hasConcept C143065580 @default.
• W2126275910 hasConcept C1491633281 @default.
• W2126275910 hasConcept C168240541 @default.
• W2126275910 hasConcept C175969161 @default.
• W2126275910 hasConcept C190062978 @default.
• W2126275910 hasConcept C199528912 @default.
• W2126275910 hasConcept C2775889303 @default.

• next