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• W2126281354 endingPage "7744" @default.
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• W2126281354 abstract "ABSTRACT Cytomegalovirus (CMV) infection during the transient immunodeficiency after bone marrow transplantation (BMT) develops into disease unless antiviral CD8 T cells are restored in due course. Histoincompatibility between donor and recipient is associated with increased risk. Complications may include a rejection response against the foreign major histocompatibility complex (MHC) antigens and a lack of antiviral control resulting from a misfit between donor-derived T cells and the antigenic viral peptides presented in recipient tissues. Here we have established a murine model of CMV disease after experimental BMT performed across a single MHC class I disparity. Specifically, BALB/c bone marrow cells expressing the prevailing antigen-presenting molecule L d were transplanted into the L d gene deletion mutant BALB/c-H-2 dm2 , an experimental setting that entails a selective risk of host-versus-graft but not graft-versus-host response. The reconstituted T-cell population proved to be chimeric in that it consisted of L d -positive donor-derived and L d -negative recipient-derived cells. Pulmonary infiltrates did not include cytolytic T cells directed against L d . This finding implies that the infection did not trigger a host-versus-graft response. Notably, upon adoptive transfer, donor-derived CD8 T cells preferentially protected tissues of donor genotype, whereas recipient-derived CD8 T cells protected tissues of either genotype. We infer from these data that the focus on immunodominant antigens presented by L d within the donor cell population distracted the donor T cells from protecting recipient tissues and that protection in the chimeras was therefore primarily based on recipient T cells. As a consequence, T-cell chimerism after BMT should give a positive prognosis with respect to control of CMV." @default.
• W2126281354 created "2016-06-24" @default.
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• W2126281354 date "1998-10-01" @default.
• W2126281354 modified "2023-10-11" @default.
• W2126281354 title "Control of Cytomegalovirus in Bone Marrow Transplantation Chimeras Lacking the Prevailing Antigen-Presenting Molecule in Recipient Tissues Rests Primarily on Recipient-Derived CD8 T Cells" @default.
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• W2126281354 doi "https://doi.org/10.1128/jvi.72.10.7733-7744.1998" @default.
• W2126281354 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/110079" @default.
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