Matches in SemOpenAlex for { <https://semopenalex.org/work/W2126290546> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2126290546 abstract "The reported ability of benzodiazepines to increase human erythrocyte aldehyde dehydrogenase (ALDH) activity and reverse the disulfiram-induced inhibition of ALDH was reexamined. When ALDH activity assays were carried out spectrophotometrically on a hemoglobin-free lysate of human erythrocytes with propionaldehyde as substrate, addition of diazepam (10 mumol/l) did not affect the enzyme activity. When assays were carried out on intact or hemolysed erythrocytes using high performance liquid chromatographic technique with 3,4-dihydroxyphenylacetaldehyde as substrate, no significant increase in erythrocyte ALDH activity was found in the presence of chlordiazepoxide, oxazepam, diazepam, or desmethyldiazepam in the concentration range 1-20 mumol/l. Rather, a significant decrease (about 50%) in activity was obtained when lysed cells were incubated with 20 mumol/l chlordiazepoxide. Diazepam inhibited the rat liver mitochondrial low Km ALDH activity by about 50%. Disulfiram inhibited the ALDH activity almost completely in assays on human erythrocyte or rat liver mitochondrial ALDH. The ALDH activity was not regained by the subsequent addition of diazepam, nor was the effect of disulfiram reduced when diazepam was added prior to disulfiram. In an alcoholic subject who was followed during onset of disulfiram (Antabuse) therapy, the concurrent use of diazepam did not prevent a rapid decline in blood ALDH activity. The present results suggest that benzodiazepines do not increase ALDH activity in vitro, nor interfere with the inhibition of ALDH by disulfiram." @default.
- W2126290546 created "2016-06-24" @default.
- W2126290546 creator A5002344568 @default.
- W2126290546 creator A5016521228 @default.
- W2126290546 date "1995-09-01" @default.
- W2126290546 modified "2023-10-02" @default.
- W2126290546 title "Effects of benzodiazepines on aldehyde dehydrogenase activity" @default.
- W2126290546 cites W1970134697 @default.
- W2126290546 cites W1970899404 @default.
- W2126290546 cites W1975143221 @default.
- W2126290546 cites W1984073023 @default.
- W2126290546 cites W1986963936 @default.
- W2126290546 cites W2001382945 @default.
- W2126290546 cites W2017547223 @default.
- W2126290546 cites W2021590859 @default.
- W2126290546 cites W2025200367 @default.
- W2126290546 cites W2029707727 @default.
- W2126290546 cites W2068608381 @default.
- W2126290546 cites W2075672529 @default.
- W2126290546 cites W2152113667 @default.
- W2126290546 cites W2398056227 @default.
- W2126290546 cites W2415093762 @default.
- W2126290546 doi "https://doi.org/10.1016/0741-8329(95)00011-f" @default.
- W2126290546 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8519435" @default.
- W2126290546 hasPublicationYear "1995" @default.
- W2126290546 type Work @default.
- W2126290546 sameAs 2126290546 @default.
- W2126290546 citedByCount "0" @default.
- W2126290546 crossrefType "journal-article" @default.
- W2126290546 hasAuthorship W2126290546A5002344568 @default.
- W2126290546 hasAuthorship W2126290546A5016521228 @default.
- W2126290546 hasConcept C170493617 @default.
- W2126290546 hasConcept C181199279 @default.
- W2126290546 hasConcept C185592680 @default.
- W2126290546 hasConcept C25747580 @default.
- W2126290546 hasConcept C2776175493 @default.
- W2126290546 hasConcept C2776615572 @default.
- W2126290546 hasConcept C2777595113 @default.
- W2126290546 hasConcept C2778173252 @default.
- W2126290546 hasConcept C2778325228 @default.
- W2126290546 hasConcept C2778523461 @default.
- W2126290546 hasConcept C2780161600 @default.
- W2126290546 hasConcept C55493867 @default.
- W2126290546 hasConcept C71924100 @default.
- W2126290546 hasConcept C98274493 @default.
- W2126290546 hasConceptScore W2126290546C170493617 @default.
- W2126290546 hasConceptScore W2126290546C181199279 @default.
- W2126290546 hasConceptScore W2126290546C185592680 @default.
- W2126290546 hasConceptScore W2126290546C25747580 @default.
- W2126290546 hasConceptScore W2126290546C2776175493 @default.
- W2126290546 hasConceptScore W2126290546C2776615572 @default.
- W2126290546 hasConceptScore W2126290546C2777595113 @default.
- W2126290546 hasConceptScore W2126290546C2778173252 @default.
- W2126290546 hasConceptScore W2126290546C2778325228 @default.
- W2126290546 hasConceptScore W2126290546C2778523461 @default.
- W2126290546 hasConceptScore W2126290546C2780161600 @default.
- W2126290546 hasConceptScore W2126290546C55493867 @default.
- W2126290546 hasConceptScore W2126290546C71924100 @default.
- W2126290546 hasConceptScore W2126290546C98274493 @default.
- W2126290546 hasLocation W21262905461 @default.
- W2126290546 hasLocation W21262905462 @default.
- W2126290546 hasOpenAccess W2126290546 @default.
- W2126290546 hasPrimaryLocation W21262905461 @default.
- W2126290546 hasRelatedWork W179028651 @default.
- W2126290546 hasRelatedWork W1970134697 @default.
- W2126290546 hasRelatedWork W2012882007 @default.
- W2126290546 hasRelatedWork W2035206694 @default.
- W2126290546 hasRelatedWork W2043294920 @default.
- W2126290546 hasRelatedWork W2114347042 @default.
- W2126290546 hasRelatedWork W2126290546 @default.
- W2126290546 hasRelatedWork W2413185667 @default.
- W2126290546 hasRelatedWork W2413772639 @default.
- W2126290546 hasRelatedWork W74216759 @default.
- W2126290546 isParatext "false" @default.
- W2126290546 isRetracted "false" @default.
- W2126290546 magId "2126290546" @default.
- W2126290546 workType "article" @default.