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• W2126292029 endingPage "801" @default.
• W2126292029 startingPage "792" @default.
• W2126292029 abstract "Summary The C hildren's O ncology G roup's A5971 trial examined central nervous system ( CNS ) prophylaxis and early intensification in paediatric patients diagnosed with CNS ‐negative Stage III and IV lymphoblastic lymphoma. Using a 2 × 2 factorial design, the study randomized patients to C hildren's C ancer G roup ( CCG ) modified Berlin‐Frankfurt‐Muenster ( BFM ) acute lymphoblastic leukaemia ( ALL ) regimen with intensified intrathecal ( IT ) methotrexate ( MTX ) (Arm A1) or an adapted non‐Hodgkin lymphoma/ BFM ‐95 therapy with high dose MTX in interim maintenance but no IT ‐ MTX in maintenance (Arm B1) . Each cohort was randomized ± intensification (cyclophosphamide/anthracycline) (Arms A2/B2). For the 254 randomized patients, there was no difference in 5‐year event‐free survival ( EFS ) for the four arms: Arm A1 , 80% [95% confidence interval ( CI ) 67–89%] and Arm A2 , 81% (95% CI 69–89%); Arm B1 , 80% (95% CI 68–88%) and Arm B2 , 84% (95% CI 72–91%). The cumulative incidence of CNS relapse was 1·2%. Age <10 years and institutional imaging response at 2 weeks was associated with improved outcomes ( P < 0·001 and P = 0·014 for overall survival). CNS positive patients ( n = 12) did poorly [5‐year EFS of 63% (95% CI 29–85%)]. For CNS ‐negative patients, there was no difference in outcome based on CNS prophylaxis ( IT ‐ MTX versus HD ‐ MTX ) or with intensification." @default.
• W2126292029 created "2016-06-24" @default.
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• W2126292029 date "2013-07-24" @default.
• W2126292029 modified "2023-10-04" @default.
• W2126292029 title "Disseminated lymphoblastic lymphoma in children and adolescents: results of the COG A5971 trial: a report from the Children's Oncology Group" @default.
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• W2126292029 doi "https://doi.org/10.1111/bjh.12460" @default.
• W2126292029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23889312" @default.
• W2126292029 hasPublicationYear "2013" @default.
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