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• W2126294067 abstract "Abstract Aim: In the present study, we assessed the role of 5‐hydroxytryptamine (5‐HT) receptors (5‐HT 1A , 5‐HT 2 and 5‐HT 7 ) in the nucleus raphe magnus (NRM) on the ventilatory and thermoregulatory responses to hypoxia. Methods: To this end, pulmonary ventilation ( V E ) and body temperature ( T b ) of male Wistar rats were measured in conscious rats, before and after a 0.1 μL microinjection of WAY‐100635 (5‐HT 1A receptor antagonist, 3 μg 0.1μL −1 , 56 m m ), ketanserin (5‐HT 2 receptor antagonist, 2 μg 0.1μL −1 , 36 m m ) and SB269970 (5‐HT 7 receptor antagonist, 4 μg 0.1 μL −1 , 103 m m ) into the NRM, followed by 60 min of severe hypoxia exposure (7% O 2 ). Results: Intra‐NMR microinjection of vehicle (control rats) or 5‐HT antagonists did not affect V E or T b during normoxic conditions. Exposure of rats to 7% O 2 evoked a typical hypoxia‐induced anapyrexia after vehicle microinjections, which was not affected by microinjection of WAY‐100635, SB269970 or ketanserin. The hypoxia‐induced hyperpnoea was not affected by SB269970 and ketanserin intra‐NMR. However, the treatment with WAY‐100635 intra‐NRM attenuated the hypoxia‐induced hyperpnoea. Conclusion: These data suggest that 5‐HT acting on 5‐HT 1A receptors in the NRM increases the hypoxic ventilatory response." @default.
• W2126294067 created "2016-06-24" @default.
• W2126294067 creator A5000194947 @default.
• W2126294067 creator A5017537629 @default.
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• W2126294067 date "2008-07-08" @default.
• W2126294067 modified "2023-10-12" @default.
• W2126294067 title "5-HT_1A, but not 5-HT₂and 5-HT₇, receptors in the nucleus raphe magnus modulate hypoxia-induced hyperpnoea" @default.
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• W2126294067 doi "https://doi.org/10.1111/j.1748-1716.2008.01853.x" @default.
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