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- W2126311929 endingPage "564" @default.
- W2126311929 startingPage "552" @default.
- W2126311929 abstract "MicroRNAs (miRNAs) are small RNA molecules involved in the regulation of mammalian gene expression. Together with other transcription regulators, miRNAs modulate the expression of genes and thereby potentially contribute to tissue and species diversity. To identify miRNAs that are differentially expressed between tissues and/or species, and the genes regulated by these, we have quantified expression of miRNAs and messenger RNAs in five tissues from multiple human, chimpanzee, and rhesus macaque individuals using high-throughput sequencing. The breadth of this tissue and species data allows us to show that downregulation of target genes by miRNAs is more pronounced between tissues than between species and that downregulation is more pronounced for genes with fewer binding sites for expressed miRNAs. Intriguingly, we find that tissue- and species-specific miRNAs target transcription factor genes (TFs) significantly more often than expected. Through their regulatory effect on transcription factors, miRNAs may therefore exert an indirect influence on a larger proportion of genes than previously thought." @default.
- W2126311929 created "2016-06-24" @default.
- W2126311929 creator A5004064619 @default.
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- W2126311929 date "2012-01-01" @default.
- W2126311929 modified "2023-10-16" @default.
- W2126311929 title "Transcription Factors Are Targeted by Differentially Expressed miRNAs in Primates" @default.
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- W2126311929 cites W1967543716 @default.
- W2126311929 cites W1977733607 @default.
- W2126311929 cites W1978337436 @default.
- W2126311929 cites W1987504428 @default.
- W2126311929 cites W1988163167 @default.
- W2126311929 cites W1993651315 @default.
- W2126311929 cites W1994263090 @default.
- W2126311929 cites W1995744844 @default.
- W2126311929 cites W2000805034 @default.
- W2126311929 cites W2003952411 @default.
- W2126311929 cites W2004271888 @default.
- W2126311929 cites W2008273315 @default.
- W2126311929 cites W2010012954 @default.
- W2126311929 cites W2014279841 @default.
- W2126311929 cites W2017408113 @default.
- W2126311929 cites W2026570544 @default.
- W2126311929 cites W2028106094 @default.
- W2126311929 cites W2034299131 @default.
- W2126311929 cites W2035864975 @default.
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- W2126311929 cites W2049291669 @default.
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- W2126311929 cites W2057346914 @default.
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- W2126311929 cites W2077879161 @default.
- W2126311929 cites W2078993539 @default.
- W2126311929 cites W2082684480 @default.
- W2126311929 cites W2088390270 @default.
- W2126311929 cites W2093956979 @default.
- W2126311929 cites W2094036688 @default.
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- W2126311929 doi "https://doi.org/10.1093/gbe/evs033" @default.
- W2126311929 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3342879" @default.
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- W2126311929 hasPublicationYear "2012" @default.
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