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- W2126314169 abstract "Tumor associated antigen (TAA)-based therapeutic vaccines have great potential as a safe, practical, and cost-efficient alternative to standard treatments for cancer. Clinical efficacy of TAA-based vaccines, however, has yet to be realized and will require adjuvants with pleiotropic functions on immune cells. Such adjuvants need not only to generate/boost T cell responses, but also reverse intrinsic/extrinsic tumor immune evasion mechanisms for therapeutic efficacy. This review focuses on a novel agonistic ligand, SA-4-1BBL, for 4-1BB costimulatory receptor as an adjuvant of choice because of its ability to: i) serve as a vehicle to deliver TAAs to dendritic cells (DCs) for antigen uptake and cross-presentation to CD8(+) T cells; ii) augment adaptive Th1 and innate immune responses; and iii) overcome various immune evasion mechanisms, cumulatively translating into therapeutic efficacy in preclinical tumor models." @default.
- W2126314169 created "2016-06-24" @default.
- W2126314169 creator A5049976699 @default.
- W2126314169 creator A5056979857 @default.
- W2126314169 creator A5077060710 @default.
- W2126314169 date "2014-02-13" @default.
- W2126314169 modified "2023-09-25" @default.
- W2126314169 title "SA-4-1BBL as a novel adjuvant for the development of therapeutic cancer vaccines" @default.
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- W2126314169 doi "https://doi.org/10.1586/14760584.2014.880340" @default.
- W2126314169 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4721633" @default.
- W2126314169 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24521311" @default.
- W2126314169 hasPublicationYear "2014" @default.
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