Matches in SemOpenAlex for { <https://semopenalex.org/work/W2126315140> ?p ?o ?g. }
- W2126315140 endingPage "818" @default.
- W2126315140 startingPage "804" @default.
- W2126315140 abstract "The first application of gas chromatography mass spectrometry (GC–MS) metabolomics to the analysis of organic acid profiles in sera of asymptomatic human immunodeficiency virus (HIV)-infected individuals (n = 18) compared to uninfected controls (n = 21), is reported here. Several organic acids are well-established diagnostic biomarkers of mitochondrial dysfunction, making the analysis of the organic acid metabolome well suited to monitoring the progressive disruption of mitochondrial structure and function during HIV infection. Using a multifaceted analytical-bioinformatics procedure, at least 10 of these metabolites could be linked to (1) disrupted mitochondrial metabolism, (2) changes in lipid metabolism and (3) oxidative stress, all of which are aberrations caused by HIV infection. Because of the role of the mitochondria in apoptosis, higher levels of this type of cell death in infected (compared to uninfected) individuals was used to support GC–MS data. This study demonstrates that mass spectrometry metabolomics detects biomarkers of mitochondrial dysfunction which could potentially be developed into indicators of HIV infection, perhaps also to monitor disease progression and the response to antiretroviral treatment." @default.
- W2126315140 created "2016-06-24" @default.
- W2126315140 creator A5004366284 @default.
- W2126315140 creator A5013480650 @default.
- W2126315140 creator A5017430723 @default.
- W2126315140 creator A5076235338 @default.
- W2126315140 creator A5081820908 @default.
- W2126315140 date "2011-10-25" @default.
- W2126315140 modified "2023-09-23" @default.
- W2126315140 title "Qualitative serum organic acid profiles of HIV-infected individuals not on antiretroviral treatment" @default.
- W2126315140 cites W1490698201 @default.
- W2126315140 cites W1584158731 @default.
- W2126315140 cites W1970101659 @default.
- W2126315140 cites W1973344445 @default.
- W2126315140 cites W1977027255 @default.
- W2126315140 cites W1981928556 @default.
- W2126315140 cites W1988438239 @default.
- W2126315140 cites W1990098732 @default.
- W2126315140 cites W1998033595 @default.
- W2126315140 cites W2012696260 @default.
- W2126315140 cites W2015837853 @default.
- W2126315140 cites W2016973128 @default.
- W2126315140 cites W2017506227 @default.
- W2126315140 cites W2023535481 @default.
- W2126315140 cites W2027420898 @default.
- W2126315140 cites W2027822830 @default.
- W2126315140 cites W2028403153 @default.
- W2126315140 cites W2031887687 @default.
- W2126315140 cites W2032485357 @default.
- W2126315140 cites W2039077785 @default.
- W2126315140 cites W2039856595 @default.
- W2126315140 cites W2047032682 @default.
- W2126315140 cites W2051805111 @default.
- W2126315140 cites W2052882967 @default.
- W2126315140 cites W2055757491 @default.
- W2126315140 cites W2055833428 @default.
- W2126315140 cites W2060952451 @default.
- W2126315140 cites W2066000358 @default.
- W2126315140 cites W2071534982 @default.
- W2126315140 cites W2078270449 @default.
- W2126315140 cites W2078378643 @default.
- W2126315140 cites W2080222756 @default.
- W2126315140 cites W2080373548 @default.
- W2126315140 cites W2081200884 @default.
- W2126315140 cites W2088696081 @default.
- W2126315140 cites W2099787406 @default.
- W2126315140 cites W2103860618 @default.
- W2126315140 cites W2106736210 @default.
- W2126315140 cites W2132679945 @default.
- W2126315140 cites W2141204624 @default.
- W2126315140 cites W2141563676 @default.
- W2126315140 cites W2146446574 @default.
- W2126315140 cites W2152197563 @default.
- W2126315140 cites W2153774266 @default.
- W2126315140 cites W2155680682 @default.
- W2126315140 cites W2164547853 @default.
- W2126315140 cites W2164583936 @default.
- W2126315140 cites W2322569173 @default.
- W2126315140 cites W2396964508 @default.
- W2126315140 cites W242053753 @default.
- W2126315140 cites W4234806062 @default.
- W2126315140 cites W4294107304 @default.
- W2126315140 doi "https://doi.org/10.1007/s11306-011-0376-2" @default.
- W2126315140 hasPublicationYear "2011" @default.
- W2126315140 type Work @default.
- W2126315140 sameAs 2126315140 @default.
- W2126315140 citedByCount "18" @default.
- W2126315140 countsByYear W21263151402012 @default.
- W2126315140 countsByYear W21263151402013 @default.
- W2126315140 countsByYear W21263151402014 @default.
- W2126315140 countsByYear W21263151402017 @default.
- W2126315140 countsByYear W21263151402018 @default.
- W2126315140 countsByYear W21263151402019 @default.
- W2126315140 countsByYear W21263151402021 @default.
- W2126315140 countsByYear W21263151402023 @default.
- W2126315140 crossrefType "journal-article" @default.
- W2126315140 hasAuthorship W2126315140A5004366284 @default.
- W2126315140 hasAuthorship W2126315140A5013480650 @default.
- W2126315140 hasAuthorship W2126315140A5017430723 @default.
- W2126315140 hasAuthorship W2126315140A5076235338 @default.
- W2126315140 hasAuthorship W2126315140A5081820908 @default.
- W2126315140 hasBestOaLocation W21263151402 @default.
- W2126315140 hasConcept C135870905 @default.
- W2126315140 hasConcept C142724271 @default.
- W2126315140 hasConcept C159047783 @default.
- W2126315140 hasConcept C190283241 @default.
- W2126315140 hasConcept C21565614 @default.
- W2126315140 hasConcept C2776151105 @default.
- W2126315140 hasConcept C2777910003 @default.
- W2126315140 hasConcept C28859421 @default.
- W2126315140 hasConcept C3013748606 @default.
- W2126315140 hasConcept C55493867 @default.
- W2126315140 hasConcept C60644358 @default.
- W2126315140 hasConcept C71924100 @default.
- W2126315140 hasConcept C86803240 @default.
- W2126315140 hasConceptScore W2126315140C135870905 @default.
- W2126315140 hasConceptScore W2126315140C142724271 @default.
- W2126315140 hasConceptScore W2126315140C159047783 @default.