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- W2126315311 abstract "1. It has been demonstrated that the ingestion of foods containing quercetin protects against the toxicity of single pesticides. The aim of this study is to make a comprehensive elaboration about the protective effect of quercetin against multi-organophosphorous pesticides induced nephrotoxicity by measuring indices in rat kidney, urine and serum. Rats were divided into six groups (n = 10/group): control, two different doses of quercetin, pesticide mixture (PM), and different doses of quercetin plus PM-treated groups. 2. The following parameters were significantly changed in PM-treated groups compared with the control (p < 0.01). In kidney, malondialdehyde level raised; catalase, superoxide dismutase activities and glutathione levels were decreased. Comet assay of nephrocytes showed that the proportion of DNA in the tail and tail length increased. In urine, β2-microglobulin, retinol-conjugated protein levels and N-acetyl-β-D-glucosaminidase activity showed increasing response; meanwhile uric acid level was decreased. In serum, creatinine and urea nitrogen levels were increased. However, the anomaly changes of indexes mentioned above in PM-treated group were alleviated when simultaneously administrated with 50 mg/kg body weight/day quercetin (p < 0.05). 3. From the present findings, it can be evaluated that quercetin may protect against adverse effects resulted from multi-organophosphorous pesticides with significant high levels of uptake in man provided." @default.
- W2126315311 created "2016-06-24" @default.
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- W2126315311 date "2015-07-30" @default.
- W2126315311 modified "2023-10-12" @default.
- W2126315311 title "Effect of quercetin against mixture of four organophosphate pesticides induced nephrotoxicity in rats" @default.
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- W2126315311 doi "https://doi.org/10.3109/00498254.2015.1070443" @default.
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