Matches in SemOpenAlex for { <https://semopenalex.org/work/W2126329290> ?p ?o ?g. }
- W2126329290 endingPage "1001" @default.
- W2126329290 startingPage "987" @default.
- W2126329290 abstract "Although stroke remains a leading cause of death and adult disability, numerous recent failures in clinical stroke trials have led to some pessimism in the field. Interestingly, NeuroAid (MLC601), a traditional medicine, particularly used in China, South East Asia and Middle East has been reported to have beneficial effects in patients, particularly in post-stroke complications. Here, we demonstrate in a rodent model of focal ischemia that NeuroAid II (MLC901) pre- and post-treatments up to 3 h after stroke improve survival, protect the brain from the ischemic injury and drastically decrease functional deficits. MLC601 and MLC901 also prevent neuronal death in an in vitro model of excitotoxicity using primary cultures of cortical neurons exposed to glutamate. In addition, MLC601/MLC901 treatments were shown to induce neurogenesis in rodent and human cells, promote cell proliferation as well as neurite outgrowth and stimulate the development of a dense axonal and dendritic network. MLC601 and MLC901 clearly represent a very interesting strategy for stroke treatment at different stages of the disease." @default.
- W2126329290 created "2016-06-24" @default.
- W2126329290 creator A5009977432 @default.
- W2126329290 creator A5030301661 @default.
- W2126329290 creator A5042613846 @default.
- W2126329290 creator A5050660601 @default.
- W2126329290 creator A5064103293 @default.
- W2126329290 creator A5064887458 @default.
- W2126329290 creator A5068045779 @default.
- W2126329290 creator A5072021092 @default.
- W2126329290 date "2010-06-01" @default.
- W2126329290 modified "2023-10-16" @default.
- W2126329290 title "Neuroprotective and neuroproliferative activities of NeuroAid (MLC601, MLC901), a Chinese medicine, in vitro and in vivo" @default.
- W2126329290 cites W1523671473 @default.
- W2126329290 cites W1936194029 @default.
- W2126329290 cites W1967239173 @default.
- W2126329290 cites W1969974084 @default.
- W2126329290 cites W1972812522 @default.
- W2126329290 cites W1974814389 @default.
- W2126329290 cites W1977228353 @default.
- W2126329290 cites W1979561481 @default.
- W2126329290 cites W1980552247 @default.
- W2126329290 cites W1983089266 @default.
- W2126329290 cites W1983162239 @default.
- W2126329290 cites W1985247035 @default.
- W2126329290 cites W1986346910 @default.
- W2126329290 cites W1987561860 @default.
- W2126329290 cites W1990281869 @default.
- W2126329290 cites W1991545156 @default.
- W2126329290 cites W1996660321 @default.
- W2126329290 cites W2000797303 @default.
- W2126329290 cites W2003801881 @default.
- W2126329290 cites W2008303238 @default.
- W2126329290 cites W2009702200 @default.
- W2126329290 cites W2010980945 @default.
- W2126329290 cites W2019588794 @default.
- W2126329290 cites W2024677061 @default.
- W2126329290 cites W2032290073 @default.
- W2126329290 cites W2032444015 @default.
- W2126329290 cites W2033284482 @default.
- W2126329290 cites W2033564977 @default.
- W2126329290 cites W2040868194 @default.
- W2126329290 cites W2044162798 @default.
- W2126329290 cites W2047478188 @default.
- W2126329290 cites W2053979603 @default.
- W2126329290 cites W2054042060 @default.
- W2126329290 cites W2058925305 @default.
- W2126329290 cites W2060545591 @default.
- W2126329290 cites W2061161895 @default.
- W2126329290 cites W2062898068 @default.
- W2126329290 cites W2071479387 @default.
- W2126329290 cites W2071969118 @default.
- W2126329290 cites W2074187719 @default.
- W2126329290 cites W2076555882 @default.
- W2126329290 cites W2078946162 @default.
- W2126329290 cites W2084681734 @default.
- W2126329290 cites W2084995170 @default.
- W2126329290 cites W2085273994 @default.
- W2126329290 cites W2086103328 @default.
- W2126329290 cites W2090322437 @default.
- W2126329290 cites W2090435870 @default.
- W2126329290 cites W2095191234 @default.
- W2126329290 cites W2106578597 @default.
- W2126329290 cites W2110442840 @default.
- W2126329290 cites W2122922916 @default.
- W2126329290 cites W2135634299 @default.
- W2126329290 cites W2152069828 @default.
- W2126329290 cites W2163529521 @default.
- W2126329290 cites W2166346391 @default.
- W2126329290 doi "https://doi.org/10.1016/j.neuropharm.2010.01.001" @default.
- W2126329290 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20064536" @default.
- W2126329290 hasPublicationYear "2010" @default.
- W2126329290 type Work @default.
- W2126329290 sameAs 2126329290 @default.
- W2126329290 citedByCount "94" @default.
- W2126329290 countsByYear W21263292902012 @default.
- W2126329290 countsByYear W21263292902013 @default.
- W2126329290 countsByYear W21263292902014 @default.
- W2126329290 countsByYear W21263292902015 @default.
- W2126329290 countsByYear W21263292902016 @default.
- W2126329290 countsByYear W21263292902017 @default.
- W2126329290 countsByYear W21263292902018 @default.
- W2126329290 countsByYear W21263292902019 @default.
- W2126329290 countsByYear W21263292902020 @default.
- W2126329290 countsByYear W21263292902021 @default.
- W2126329290 countsByYear W21263292902022 @default.
- W2126329290 countsByYear W21263292902023 @default.
- W2126329290 crossrefType "journal-article" @default.
- W2126329290 hasAuthorship W2126329290A5009977432 @default.
- W2126329290 hasAuthorship W2126329290A5030301661 @default.
- W2126329290 hasAuthorship W2126329290A5042613846 @default.
- W2126329290 hasAuthorship W2126329290A5050660601 @default.
- W2126329290 hasAuthorship W2126329290A5064103293 @default.
- W2126329290 hasAuthorship W2126329290A5064887458 @default.
- W2126329290 hasAuthorship W2126329290A5068045779 @default.
- W2126329290 hasAuthorship W2126329290A5072021092 @default.
- W2126329290 hasConcept C113246987 @default.
- W2126329290 hasConcept C126322002 @default.