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- W2126331122 abstract "Materials that combine facile synthesis, simple tuning of degradation rate, processability, and biocompatibility are in high demand for use in biomedical applications. We report on acetalated dextran, a biocompatible material that can be formed into microparticles with degradation rates that are tunable over 2 orders of magnitude depending on the degree and type of acetal modification. Varying the degradation rate produces particles that perform better than poly(lactic- co -glycolic acid) and iron oxide, two commonly studied materials used for particulate immunotherapy, in major histocompatibility complex class I (MHC I) and MHC II presentation assays. Modulating the material properties leads to antigen presentation on MHC I via pathways that are dependent or independent of the transporter associated with antigen processing. To the best of our knowledge, this is the only example of a material that can be tuned to operate on different immunological pathways while maximizing immunological presentation." @default.
- W2126331122 created "2016-06-24" @default.
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- W2126331122 date "2009-04-07" @default.
- W2126331122 modified "2023-10-03" @default.
- W2126331122 title "Acetalated dextran is a chemically and biologically tunable material for particulate immunotherapy" @default.
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- W2126331122 doi "https://doi.org/10.1073/pnas.0901592106" @default.
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