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- W2126367887 endingPage "98" @default.
- W2126367887 startingPage "89" @default.
- W2126367887 abstract "Studies of mutagenesis in many organisms indicate that the majority (over 90%) of mutations are recessive to wild type. If recessiveness represents the 9default9 state, what are the distinguishing features that make a minority of mutations give rise to dominant or semidominant characters? This review draws on the rapid expansion in knowledge of molecular and cellular biology to classify the molecular mechanisms of dominant mutation. The categories discussed include (1) reduced gene dosage, expression, or protein activity (haploinsufficiency); (2) increased gene dosage; (3) ectopic or temporally altered mRNA expression; (4) increased or constitutive protein activity; (5) dominant negative effects; (6) altered structural proteins; (7) toxic protein alterations; and (8) new protein functions. This provides a framework for understanding the basis of dominant genetic phenomena in humans and other organisms." @default.
- W2126367887 created "2016-06-24" @default.
- W2126367887 creator A5015376243 @default.
- W2126367887 date "1994-02-01" @default.
- W2126367887 modified "2023-10-16" @default.
- W2126367887 title "The molecular basis of genetic dominance." @default.
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