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- W2126375858 abstract "Recently, several publications have confirmed the association between pergolide use and valvular heart disease (VHD).1–3 The serotonin 2B (5HT2b) receptor has been proposed as the key pathway through which pergolide and other drugs activate valvular fibroblasts to proliferate and to produce myxoid substance and collagen, leading to valvular thickening and insufficiency.4 This can explain the occurrence of VHD with 5HT2b agonists such as pergolide and cabergoline, while drugs without 5HT2b activity have not been reported to cause valvulopathy (i.e. pramipexole, lisuride). These recent findings have led to the voluntary withdrawal of pergolide in the US (mars 2007) and to an increased awareness of, and recommendations for a more careful use of pergolide by neurologists in Europe. The studies that reported an association between pergolide and VHD were mainly conducted in older patients with Parkinson's disease who usually require higher dosages of pergolide compared with patients with restless leg syndrome or hyperprolactinemia. Even at low dose, pergolide remains also useful for many …" @default.
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- W2126375858 date "2008-05-10" @default.
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- W2126375858 title "Pergolide and valvular heart disease: the lower the better?" @default.
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- W2126375858 doi "https://doi.org/10.1093/ejechocard/jen202" @default.
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