FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2126382018> ?p ?o ?g. }

• W2126382018 endingPage "1597" @default.
• W2126382018 startingPage "1597" @default.
• W2126382018 abstract "To investigate the expression of genes involved in the gemcitabine-induced cytotoxicity in human pancreatic cancer cells.A human pancreatic cancer cell line, PANC-1, was cultured. 1x10(4) PANC-1 cells were plated in 96-well microtiter plates. After being incubated for 24 h, gemcitabine was added to the medium at concentrations ranging 2.5-1000 mg/L. The AlamarBlue dye method was used for cell growth analysis. DNA fragmentation was quantitatively assayed using a DNA fragmentation enzyme-linked immunosorbent assay (ELISA) kit. PAP and TP53INP1 mRNA expression was determined using the reverse transcription-polymerase chain reaction with semi-quantitative analysis. The expression of GSK-3beta and phospho-GSK-3beta proteins was examined with Western blot analysis.The IC50 for the drug after a 48-h exposure to gemcitabine was 16 mg/L. The growth of PANC-1 cells was inhibited by gemcitabine in a concentration-dependent manner (P<0.0001) and the cell growth was also inhibited throughout the time course (P<0.0001). The DNA fragmentation rate in the gemcitabine-treated group at 48 h was 44.7%, whereas it was 25.3% in the untreated group. The PAP mRNA expression was decreased after being treated with gemcitabine, whereas the TP53INP1 mRNA was increased by the gemcitabine treatment. Western blot analysis showed that phospho- GSK-3beta (ser9) was induced by the gemcitabine treatment.Gemcitabine suppresses PANC-1 cell proliferation and induces apoptosis. Apoptosis is considered to be associated with the inhibition of PAP and GSK-3beta, and the activation of TP53INP1 and pospho-GSK-3beta (ser9)." @default.
• W2126382018 created "2016-06-24" @default.
• W2126382018 creator A5008116561 @default.
• W2126382018 creator A5011230805 @default.
• W2126382018 creator A5043001482 @default.
• W2126382018 creator A5058032939 @default.
• W2126382018 date "2006-01-01" @default.
• W2126382018 modified "2023-09-26" @default.
• W2126382018 title "Effect of gemcitabine on the expression of apoptosis-related genes in human pancreatic cancer cells" @default.
• W2126382018 cites W1563328868 @default.
• W2126382018 cites W1910707858 @default.
• W2126382018 cites W1931508686 @default.
• W2126382018 cites W1976594458 @default.
• W2126382018 cites W1979490110 @default.
• W2126382018 cites W1982925179 @default.
• W2126382018 cites W1983205679 @default.
• W2126382018 cites W1987153127 @default.
• W2126382018 cites W1993323934 @default.
• W2126382018 cites W1999653639 @default.
• W2126382018 cites W2000932071 @default.
• W2126382018 cites W2002010679 @default.
• W2126382018 cites W2010198833 @default.
• W2126382018 cites W2019378544 @default.
• W2126382018 cites W2019834670 @default.
• W2126382018 cites W2020555834 @default.
• W2126382018 cites W2029334179 @default.
• W2126382018 cites W2036364900 @default.
• W2126382018 cites W2038469623 @default.
• W2126382018 cites W2055142365 @default.
• W2126382018 cites W2057486966 @default.
• W2126382018 cites W2057722566 @default.
• W2126382018 cites W2070561129 @default.
• W2126382018 cites W2091358530 @default.
• W2126382018 cites W2091594394 @default.
• W2126382018 cites W2099814327 @default.
• W2126382018 cites W2118247947 @default.
• W2126382018 cites W2125988618 @default.
• W2126382018 cites W2168228258 @default.
• W2126382018 cites W70948226 @default.
• W2126382018 cites W98461911 @default.
• W2126382018 doi "https://doi.org/10.3748/wjg.v12.i10.1597" @default.
• W2126382018 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4124293" @default.
• W2126382018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16570353" @default.
• W2126382018 hasPublicationYear "2006" @default.
• W2126382018 type Work @default.
• W2126382018 sameAs 2126382018 @default.
• W2126382018 citedByCount "37" @default.
• W2126382018 countsByYear W21263820182012 @default.
• W2126382018 countsByYear W21263820182013 @default.
• W2126382018 countsByYear W21263820182014 @default.
• W2126382018 countsByYear W21263820182015 @default.
• W2126382018 countsByYear W21263820182017 @default.
• W2126382018 countsByYear W21263820182019 @default.
• W2126382018 countsByYear W21263820182020 @default.
• W2126382018 countsByYear W21263820182021 @default.
• W2126382018 countsByYear W21263820182022 @default.
• W2126382018 countsByYear W21263820182023 @default.
• W2126382018 crossrefType "journal-article" @default.
• W2126382018 hasAuthorship W2126382018A5008116561 @default.
• W2126382018 hasAuthorship W2126382018A5011230805 @default.
• W2126382018 hasAuthorship W2126382018A5043001482 @default.
• W2126382018 hasAuthorship W2126382018A5058032939 @default.
• W2126382018 hasBestOaLocation W21263820181 @default.
• W2126382018 hasConcept C104317684 @default.
• W2126382018 hasConcept C121608353 @default.
• W2126382018 hasConcept C153911025 @default.
• W2126382018 hasConcept C185592680 @default.
• W2126382018 hasConcept C18903297 @default.
• W2126382018 hasConcept C190283241 @default.
• W2126382018 hasConcept C191015642 @default.
• W2126382018 hasConcept C2776415932 @default.
• W2126382018 hasConcept C2780210213 @default.
• W2126382018 hasConcept C2780258809 @default.
• W2126382018 hasConcept C31573885 @default.
• W2126382018 hasConcept C43759708 @default.
• W2126382018 hasConcept C502942594 @default.
• W2126382018 hasConcept C54355233 @default.
• W2126382018 hasConcept C553184892 @default.
• W2126382018 hasConcept C55493867 @default.
• W2126382018 hasConcept C62112901 @default.
• W2126382018 hasConcept C81885089 @default.
• W2126382018 hasConcept C86803240 @default.
• W2126382018 hasConceptScore W2126382018C104317684 @default.
• W2126382018 hasConceptScore W2126382018C121608353 @default.
• W2126382018 hasConceptScore W2126382018C153911025 @default.
• W2126382018 hasConceptScore W2126382018C185592680 @default.
• W2126382018 hasConceptScore W2126382018C18903297 @default.
• W2126382018 hasConceptScore W2126382018C190283241 @default.
• W2126382018 hasConceptScore W2126382018C191015642 @default.
• W2126382018 hasConceptScore W2126382018C2776415932 @default.
• W2126382018 hasConceptScore W2126382018C2780210213 @default.
• W2126382018 hasConceptScore W2126382018C2780258809 @default.
• W2126382018 hasConceptScore W2126382018C31573885 @default.
• W2126382018 hasConceptScore W2126382018C43759708 @default.
• W2126382018 hasConceptScore W2126382018C502942594 @default.
• W2126382018 hasConceptScore W2126382018C54355233 @default.
• W2126382018 hasConceptScore W2126382018C553184892 @default.
• W2126382018 hasConceptScore W2126382018C55493867 @default.

• next