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- W2126392757 abstract "Many studies have demonstrated ω-3PUFA has anti-tumor effect, our previous study further proved that together with chemotherapy drug, PUFA can enhance chemotherapy sensitivity as well as anti-tumor effect. This study will further investigate the mechanism of enhancing chemotherapy sensitivity. In vitro cultivate human gastric cell line MGC-803, set 3 different contrast trials: control group-A, chemotherapy group-B (5-FU), n-PUFA with chemotherapy (5-FU) group-C. Compare 3 groups cells’ NF-κB activation status with dual-luciferase reporter assay and bioluminescent measurements, by using transient cotransfection with plasmid pNFκB-TK-Luc and internal control plasmid pRL-TK in MGC-803 cells. Meanwhile, compare 3 groups of the mRNA and protein expression of MMP-2, COX2, CyclinD1, which are the downstream regulation gene of NF-κB transduction pathway. NF-κB transduction was obviously activated in chemotherapy group-B, compared to the control group-A. However, in group-C, n-PUFA can blunt the NF-κB activation induced by chemotherapy. Meanwhile, the NF-κB’s downstream regulation genes, MMP-2, COX2 and CyclinD1 were also inhibited. ω-3PUFA can enhance chemotherapy sensitivity through inhibition of NF-κB transduction way. This study suggests a new concept of using clinical combination chemotherapy." @default.
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- W2126392757 date "2011-02-01" @default.
- W2126392757 modified "2023-10-15" @default.
- W2126392757 title "ω-3 Polyunsaturated fatty acid enhance chemotherapy sensitivity by inhibiting NF-κB pathway" @default.
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- W2126392757 doi "https://doi.org/10.1016/j.eclnm.2010.09.005" @default.
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