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• W2126392945 startingPage "1162" @default.
• W2126392945 abstract "Background: Antiretroviral therapy has improved the prospects for people infected with HIV, but some develop a syndrome of profound body habitus and metabolic alterations that include truncal enlargement. Objective: The purpose of this study was to define the body-composition changes associated with this syndrome by using techniques with the power to estimate regional body composition. Design: We compared whole-body and regional skeletal muscle and adipose tissue contents measured by magnetic resonance imaging and dual-energy X-ray absorptiometry (DXA) in 26 HIV-infected patients and 26 matched control subjects. Twelve of the HIV-infected patients had evidence of truncal enlargement. Results: HIV-infected men and women who noted truncal enlargement had similar amounts of skeletal muscle and subcutaneous adipose tissue but greater visceral adipose tissue than HIV-infected patients without truncal enlargement; these values were larger in men (P < 0.001) than in women (P = 0.08). The ratio of visceral to subcutaneous adipose tissue was greater in both men (P < 0.02) and women (P = 0.05) with truncal enlargement. Two subjects with MRI-confirmed visceral adiposity syndrome (VAS) were not taking protease inhibitors. CD4+ lymphocyte counts were higher (P < 0.001) and plasma viral burdens tended to be lower (P = 0.08) in HIV-infected patients with VAS. Conclusions: There was significantly more visceral adipose tissue in the subgroup of HIV-infected patients with truncal enlargement than in those without this sign. VAS occurs in both men and women, is associated with higher CD4+ lymphocyte counts and lower plasma HIV viral burdens, and is not limited to those receiving protease inhibitor therapy." @default.
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• W2126392945 date "1999-06-01" @default.
• W2126392945 modified "2023-10-01" @default.
• W2126392945 title "Fat distribution in HIV-infected patients reporting truncal enlargement quantified by whole-body magnetic resonance imaging" @default.
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• W2126392945 doi "https://doi.org/10.1093/ajcn/69.6.1162" @default.
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