FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2126394796> ?p ?o ?g. }

• W2126394796 endingPage "1673" @default.
• W2126394796 startingPage "1668" @default.
• W2126394796 abstract "We examined the possibility that the cutaneous permeability barrier regulates epidermal DNA synthesis in two acute and two chronic models of barrier perturbation. In animals treated topically with acetone, DNA synthesis is increased 102%, in tape-stripped animals 127%, in essential fatty acid deficient animals 50%, and in animals chronically treated with topical lovastatin 64%. This linkage between disturbances in barrier function and increased DNA synthesis is further supported by specific and correlative observations: (a) in these disparate models, artificial replacement of the barrier with a water-impermeable membrane inhibits the expected increase in DNA synthesis; (b) the extent of the burst in DNA synthesis is proportional to the degree of barrier abrogation; (c) the inhibition of DNA synthesis by membranes is directly related to the degree of permeability of these occlusive membranes, i.e., the more impermeable the greater the degree of inhibition; (d) topical treatment with lipids that restore barrier function corrects the increase in DNA synthesis; and (e) barrier abrogation with acetone produces an increase in epidermal DNA synthesis without altering bulk protein synthetic rates in contrast to events known to follow injury or cell replacement. Autoradiographic studies show that the increase in DNA synthesis after acetone treatment is limited to the epidermal basal layer. This constellation of findings strongly suggests that cutaneous barrier function is one factor that regulates epidermal DNA synthesis." @default.
• W2126394796 created "2016-06-24" @default.
• W2126394796 creator A5012000587 @default.
• W2126394796 creator A5050608918 @default.
• W2126394796 creator A5051847291 @default.
• W2126394796 creator A5082650655 @default.
• W2126394796 date "1991-05-01" @default.
• W2126394796 modified "2023-10-10" @default.
• W2126394796 title "Barrier function regulates epidermal DNA synthesis." @default.
• W2126394796 cites W1796779887 @default.
• W2126394796 cites W1872675327 @default.
• W2126394796 cites W1969510510 @default.
• W2126394796 cites W1979669053 @default.
• W2126394796 cites W1988794859 @default.
• W2126394796 cites W1991557802 @default.
• W2126394796 cites W1994690676 @default.
• W2126394796 cites W2008441546 @default.
• W2126394796 cites W2011586489 @default.
• W2126394796 cites W2023345794 @default.
• W2126394796 cites W2024462477 @default.
• W2126394796 cites W2030178194 @default.
• W2126394796 cites W2033799542 @default.
• W2126394796 cites W2035660063 @default.
• W2126394796 cites W2038085058 @default.
• W2126394796 cites W2055483116 @default.
• W2126394796 cites W2069948046 @default.
• W2126394796 cites W2071124826 @default.
• W2126394796 cites W2072976644 @default.
• W2126394796 cites W2077155811 @default.
• W2126394796 cites W2079357884 @default.
• W2126394796 cites W2090880744 @default.
• W2126394796 cites W2112737647 @default.
• W2126394796 cites W2120030741 @default.
• W2126394796 cites W2125149319 @default.
• W2126394796 cites W2250379301 @default.
• W2126394796 cites W2409521739 @default.
• W2126394796 cites W2413287599 @default.
• W2126394796 cites W2419277797 @default.
• W2126394796 cites W2465280077 @default.
• W2126394796 cites W4243296229 @default.
• W2126394796 doi "https://doi.org/10.1172/jci115183" @default.
• W2126394796 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/295261" @default.
• W2126394796 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2022737" @default.
• W2126394796 hasPublicationYear "1991" @default.
• W2126394796 type Work @default.
• W2126394796 sameAs 2126394796 @default.
• W2126394796 citedByCount "242" @default.
• W2126394796 countsByYear W21263947962012 @default.
• W2126394796 countsByYear W21263947962013 @default.
• W2126394796 countsByYear W21263947962014 @default.
• W2126394796 countsByYear W21263947962015 @default.
• W2126394796 countsByYear W21263947962016 @default.
• W2126394796 countsByYear W21263947962017 @default.
• W2126394796 countsByYear W21263947962019 @default.
• W2126394796 countsByYear W21263947962020 @default.
• W2126394796 countsByYear W21263947962022 @default.
• W2126394796 crossrefType "journal-article" @default.
• W2126394796 hasAuthorship W2126394796A5012000587 @default.
• W2126394796 hasAuthorship W2126394796A5050608918 @default.
• W2126394796 hasAuthorship W2126394796A5051847291 @default.
• W2126394796 hasAuthorship W2126394796A5082650655 @default.
• W2126394796 hasBestOaLocation W21263947961 @default.
• W2126394796 hasConcept C12554922 @default.
• W2126394796 hasConcept C143425029 @default.
• W2126394796 hasConcept C153911025 @default.
• W2126394796 hasConcept C185592680 @default.
• W2126394796 hasConcept C51911345 @default.
• W2126394796 hasConcept C552990157 @default.
• W2126394796 hasConcept C55493867 @default.
• W2126394796 hasConcept C64241487 @default.
• W2126394796 hasConcept C86803240 @default.
• W2126394796 hasConcept C95444343 @default.
• W2126394796 hasConceptScore W2126394796C12554922 @default.
• W2126394796 hasConceptScore W2126394796C143425029 @default.
• W2126394796 hasConceptScore W2126394796C153911025 @default.
• W2126394796 hasConceptScore W2126394796C185592680 @default.
• W2126394796 hasConceptScore W2126394796C51911345 @default.
• W2126394796 hasConceptScore W2126394796C552990157 @default.
• W2126394796 hasConceptScore W2126394796C55493867 @default.
• W2126394796 hasConceptScore W2126394796C64241487 @default.
• W2126394796 hasConceptScore W2126394796C86803240 @default.
• W2126394796 hasConceptScore W2126394796C95444343 @default.
• W2126394796 hasIssue "5" @default.
• W2126394796 hasLocation W21263947961 @default.
• W2126394796 hasLocation W21263947962 @default.
• W2126394796 hasLocation W21263947963 @default.
• W2126394796 hasLocation W21263947964 @default.
• W2126394796 hasOpenAccess W2126394796 @default.
• W2126394796 hasPrimaryLocation W21263947961 @default.
• W2126394796 hasRelatedWork W1988575162 @default.
• W2126394796 hasRelatedWork W1991900499 @default.
• W2126394796 hasRelatedWork W2015642249 @default.
• W2126394796 hasRelatedWork W2020702580 @default.
• W2126394796 hasRelatedWork W2066489051 @default.
• W2126394796 hasRelatedWork W2092875419 @default.
• W2126394796 hasRelatedWork W2126394796 @default.
• W2126394796 hasRelatedWork W2164458581 @default.
• W2126394796 hasRelatedWork W4200360487 @default.

• next