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• W2126414539 endingPage "3563" @default.
• W2126414539 startingPage "3557" @default.
• W2126414539 abstract "Abstract T cells from patients with systemic lupus erythematosus express increased levels of the cAMP response element modulator (CREM) that has been shown to bind to the IL-2 promoter and suppress its activity. In this study, we demonstrate that CREM binds to the proximal promoter of the c-fos proto-oncogene in live systemic lupus erythematosus T cells and represses its expression following stimulation in vitro. Decreased levels of c-fos protein result in decreased AP-1 activity, as determined in shift assays. Blockade of the translation of CREM mRNA with an antisense CREM vector increases the expression of c-fos and the AP-1 activity. The levels of c-fos mRNA vary with disease activity. We conclude that CREM represses the expression of c-fos and limits the activity of the enhancer AP-1. Thus, CREM is involved indirectly in the modulation of transcriptional regulation of multiple genes including IL-2." @default.
• W2126414539 created "2016-06-24" @default.
• W2126414539 creator A5027542245 @default.
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• W2126414539 creator A5048559252 @default.
• W2126414539 creator A5084356090 @default.
• W2126414539 creator A5086854418 @default.
• W2126414539 date "2004-09-01" @default.
• W2126414539 modified "2023-10-17" @default.
• W2126414539 title "Cyclic Adenosine 5′-Monophosphate Response Element Modulator Is Responsible for the Decreased Expression of c-<i>fos</i> and Activator Protein-1 Binding in T Cells from Patients with Systemic Lupus Erythematosus" @default.
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• W2126414539 doi "https://doi.org/10.4049/jimmunol.173.5.3557" @default.
• W2126414539 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15322221" @default.
• W2126414539 hasPublicationYear "2004" @default.
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