FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2126446042> ?p ?o ?g. }

• W2126446042 endingPage "261" @default.
• W2126446042 startingPage "256" @default.
• W2126446042 abstract "DS-8587 is a novel broad-spectrum fluoroquinolone with extended antimicrobial activity against both Gram-positive and Gram-negative pathogens. In this study, we evaluated the antibacterial activity and mechanism of DS-8587 in 31 quinolone-resistant Acinetobacter baumannii clinical isolates. Efflux pump and qnr genes, mutations in quinolone resistance-determining regions of target enzymes, and sequence types determined by multilocus sequence typing were analyzed. Forty-two quinolone-susceptible clinical isolates were analyzed for comparison. For susceptibility testing, DS-8587 exhibited more effective antibacterial activity when compared with ciprofloxacin and levofloxacin. When combined with the efflux pump inhibitor 1-(1-napthylmethyl)-piperazine, the MIC of DS-8587 was less affected when compared with the MIC exhibited by combined ciprofloxacin and 1-(1-napthylmethyl)-piperazine. The efflux pump genes adeA/adeB/adeC and regulatory elements adeR/adeS were detected in 23 of 31 quinolone-resistant isolates. The qnrA/qnrB/qnrS genes were not detected in any A. baumannii isolates analyzed. Mutations in quinolone resistance-determining regions were observed in all 31 quinolone-resistant isolates. Multilocus sequence typing analyses revealed that 22 of 31 quinolone-resistant isolates belonged to ST-2, corresponding to international clonal lineage II. In conclusion, DS-8587 exhibits potent antibacterial activity against quinolone-resistant A. baumannii isolates that harbor mutations in quinolone resistance-determining regions. In the presence of the efflux pump inhibitor 1-(1-napthylmethyl)-piperazine, no significant changes were observed in the MIC for DS-8587. DS-8587 should be considered as a treatment option for A. baumannii including ST-2 strains that are predominant among the quinolone-resistant A. baumannii isolates found in Japan." @default.
• W2126446042 created "2016-06-24" @default.
• W2126446042 creator A5009828089 @default.
• W2126446042 creator A5016684181 @default.
• W2126446042 creator A5048999860 @default.
• W2126446042 creator A5075361088 @default.
• W2126446042 creator A5084045447 @default.
• W2126446042 date "2014-04-01" @default.
• W2126446042 modified "2023-09-23" @default.
• W2126446042 title "Characteristics of antibiotic resistance and sequence type of Acinetobacter baumannii clinical isolates in Japan and the antibacterial activity of DS-8587" @default.
• W2126446042 cites W1505626160 @default.
• W2126446042 cites W1969307309 @default.
• W2126446042 cites W1974710065 @default.
• W2126446042 cites W1986133588 @default.
• W2126446042 cites W1988962048 @default.
• W2126446042 cites W1995360305 @default.
• W2126446042 cites W2005494343 @default.
• W2126446042 cites W2006881751 @default.
• W2126446042 cites W2008861264 @default.
• W2126446042 cites W2027720511 @default.
• W2126446042 cites W2038427300 @default.
• W2126446042 cites W2055979131 @default.
• W2126446042 cites W2058438885 @default.
• W2126446042 cites W2064153127 @default.
• W2126446042 cites W2091659282 @default.
• W2126446042 cites W2105161608 @default.
• W2126446042 cites W2115118328 @default.
• W2126446042 cites W2118031895 @default.
• W2126446042 cites W2126209681 @default.
• W2126446042 cites W2134202471 @default.
• W2126446042 cites W2134342813 @default.
• W2126446042 cites W2135113667 @default.
• W2126446042 cites W2142408159 @default.
• W2126446042 cites W2153637988 @default.
• W2126446042 cites W2154766811 @default.
• W2126446042 cites W2155948652 @default.
• W2126446042 cites W2160161568 @default.
• W2126446042 cites W2588737010 @default.
• W2126446042 doi "https://doi.org/10.1016/j.jiac.2013.12.001" @default.
• W2126446042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24709045" @default.
• W2126446042 hasPublicationYear "2014" @default.
• W2126446042 type Work @default.
• W2126446042 sameAs 2126446042 @default.
• W2126446042 citedByCount "7" @default.
• W2126446042 countsByYear W21264460422014 @default.
• W2126446042 countsByYear W21264460422015 @default.
• W2126446042 countsByYear W21264460422016 @default.
• W2126446042 countsByYear W21264460422018 @default.
• W2126446042 countsByYear W21264460422019 @default.
• W2126446042 countsByYear W21264460422020 @default.
• W2126446042 crossrefType "journal-article" @default.
• W2126446042 hasAuthorship W2126446042A5009828089 @default.
• W2126446042 hasAuthorship W2126446042A5016684181 @default.
• W2126446042 hasAuthorship W2126446042A5048999860 @default.
• W2126446042 hasAuthorship W2126446042A5075361088 @default.
• W2126446042 hasAuthorship W2126446042A5084045447 @default.
• W2126446042 hasConcept C104317684 @default.
• W2126446042 hasConcept C135763542 @default.
• W2126446042 hasConcept C200082930 @default.
• W2126446042 hasConcept C2776315533 @default.
• W2126446042 hasConcept C2777637488 @default.
• W2126446042 hasConcept C2778512257 @default.
• W2126446042 hasConcept C2778523567 @default.
• W2126446042 hasConcept C2779922871 @default.
• W2126446042 hasConcept C2781276175 @default.
• W2126446042 hasConcept C501593827 @default.
• W2126446042 hasConcept C523546767 @default.
• W2126446042 hasConcept C54355233 @default.
• W2126446042 hasConcept C77434933 @default.
• W2126446042 hasConcept C86803240 @default.
• W2126446042 hasConcept C89423630 @default.
• W2126446042 hasConceptScore W2126446042C104317684 @default.
• W2126446042 hasConceptScore W2126446042C135763542 @default.
• W2126446042 hasConceptScore W2126446042C200082930 @default.
• W2126446042 hasConceptScore W2126446042C2776315533 @default.
• W2126446042 hasConceptScore W2126446042C2777637488 @default.
• W2126446042 hasConceptScore W2126446042C2778512257 @default.
• W2126446042 hasConceptScore W2126446042C2778523567 @default.
• W2126446042 hasConceptScore W2126446042C2779922871 @default.
• W2126446042 hasConceptScore W2126446042C2781276175 @default.
• W2126446042 hasConceptScore W2126446042C501593827 @default.
• W2126446042 hasConceptScore W2126446042C523546767 @default.
• W2126446042 hasConceptScore W2126446042C54355233 @default.
• W2126446042 hasConceptScore W2126446042C77434933 @default.
• W2126446042 hasConceptScore W2126446042C86803240 @default.
• W2126446042 hasConceptScore W2126446042C89423630 @default.
• W2126446042 hasIssue "4" @default.
• W2126446042 hasLocation W21264460421 @default.
• W2126446042 hasLocation W21264460422 @default.
• W2126446042 hasOpenAccess W2126446042 @default.
• W2126446042 hasPrimaryLocation W21264460421 @default.
• W2126446042 hasRelatedWork W1532920467 @default.
• W2126446042 hasRelatedWork W1996664300 @default.
• W2126446042 hasRelatedWork W2124395666 @default.
• W2126446042 hasRelatedWork W2126446042 @default.
• W2126446042 hasRelatedWork W2135537843 @default.
• W2126446042 hasRelatedWork W2153637988 @default.
• W2126446042 hasRelatedWork W2168573732 @default.

• next