FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2126456230> ?p ?o ?g. }

• W2126456230 endingPage "8819" @default.
• W2126456230 startingPage "8809" @default.
• W2126456230 abstract "ABSTRACT Splicing of the Saccharomyces cerevisiae mitochondrial DNA group II intron aI2 depends on the intron-encoded 62-kDa reverse transcriptase-maturase protein (p62). In wild-type strains, p62 remains associated with the excised intron lariat RNA in ribonucleoprotein (RNP) particles that are essential for intron homing. Studies of a bacterial group II intron showed that the DIVa substructure of intron domain IV is a high-affinity binding site for its maturase. Here we first present in vitro evidence extending that conclusion to aI2. Then, experiments with aI2 DIVa mutant strains show that the binding of p62 to DIVa is not essential for aI2 splicing in vivo but is essential for homing. Because aI2 splicing in the DIVa mutant strains remains maturase dependent, splicing must rely on other RNA-protein contacts. The p62 that accumulates in the mutant strains has reverse transcriptase activity, but fractionation experiments at high and low salt concentrations show that it associates more weakly than the wild-type protein with endogenous mitochondrial RNAs, and that phenotype probably explains the homing defect. Replacing the DIVa of aI2 with that of the closely related intron aI1 improves in vivo splicing but not homing, indicating that DIVa contributes to the specificity of the maturase-RNA interaction needed for homing." @default.
• W2126456230 created "2016-06-24" @default.
• W2126456230 creator A5000025890 @default.
• W2126456230 creator A5003687369 @default.
• W2126456230 creator A5005988075 @default.
• W2126456230 creator A5066102428 @default.
• W2126456230 creator A5072114316 @default.
• W2126456230 creator A5091615968 @default.
• W2126456230 date "2003-12-01" @default.
• W2126456230 modified "2023-09-27" @default.
• W2126456230 title "The DIVa Maturase Binding Site in the Yeast Group II Intron aI2 Is Essential for Intron Homing but Not for In Vivo Splicing" @default.
• W2126456230 cites W104152534 @default.
• W2126456230 cites W1479790994 @default.
• W2126456230 cites W1501232407 @default.
• W2126456230 cites W1544916933 @default.
• W2126456230 cites W1546847603 @default.
• W2126456230 cites W1591250963 @default.
• W2126456230 cites W1931304055 @default.
• W2126456230 cites W1970040635 @default.
• W2126456230 cites W1975260126 @default.
• W2126456230 cites W1979171323 @default.
• W2126456230 cites W1980258137 @default.
• W2126456230 cites W1989250056 @default.
• W2126456230 cites W2004572268 @default.
• W2126456230 cites W2006183148 @default.
• W2126456230 cites W2010750399 @default.
• W2126456230 cites W2014601660 @default.
• W2126456230 cites W2017155358 @default.
• W2126456230 cites W2027361898 @default.
• W2126456230 cites W2043810954 @default.
• W2126456230 cites W2050396617 @default.
• W2126456230 cites W2055396596 @default.
• W2126456230 cites W2056412942 @default.
• W2126456230 cites W2066650456 @default.
• W2126456230 cites W2067526006 @default.
• W2126456230 cites W2071817310 @default.
• W2126456230 cites W2082856106 @default.
• W2126456230 cites W2090669079 @default.
• W2126456230 cites W2102139974 @default.
• W2126456230 cites W2102449253 @default.
• W2126456230 cites W2108318004 @default.
• W2126456230 cites W2117797684 @default.
• W2126456230 cites W2121480315 @default.
• W2126456230 cites W2123935782 @default.
• W2126456230 cites W2135242556 @default.
• W2126456230 cites W2138735124 @default.
• W2126456230 cites W2145237484 @default.
• W2126456230 cites W2147949158 @default.
• W2126456230 cites W2164178481 @default.
• W2126456230 cites W2164620523 @default.
• W2126456230 cites W2167812886 @default.
• W2126456230 cites W2176375858 @default.
• W2126456230 doi "https://doi.org/10.1128/mcb.23.23.8809-8819.2003" @default.
• W2126456230 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/262681" @default.
• W2126456230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14612420" @default.
• W2126456230 hasPublicationYear "2003" @default.
• W2126456230 type Work @default.
• W2126456230 sameAs 2126456230 @default.
• W2126456230 citedByCount "25" @default.
• W2126456230 countsByYear W21264562302013 @default.
• W2126456230 countsByYear W21264562302014 @default.
• W2126456230 countsByYear W21264562302015 @default.
• W2126456230 crossrefType "journal-article" @default.
• W2126456230 hasAuthorship W2126456230A5000025890 @default.
• W2126456230 hasAuthorship W2126456230A5003687369 @default.
• W2126456230 hasAuthorship W2126456230A5005988075 @default.
• W2126456230 hasAuthorship W2126456230A5066102428 @default.
• W2126456230 hasAuthorship W2126456230A5072114316 @default.
• W2126456230 hasAuthorship W2126456230A5091615968 @default.
• W2126456230 hasBestOaLocation W21264562302 @default.
• W2126456230 hasConcept C104317684 @default.
• W2126456230 hasConcept C118346598 @default.
• W2126456230 hasConcept C143065580 @default.
• W2126456230 hasConcept C151872237 @default.
• W2126456230 hasConcept C18903297 @default.
• W2126456230 hasConcept C54355233 @default.
• W2126456230 hasConcept C54458228 @default.
• W2126456230 hasConcept C64962909 @default.
• W2126456230 hasConcept C67705224 @default.
• W2126456230 hasConcept C86803240 @default.
• W2126456230 hasConcept C94671646 @default.
• W2126456230 hasConcept C95444343 @default.
• W2126456230 hasConceptScore W2126456230C104317684 @default.
• W2126456230 hasConceptScore W2126456230C118346598 @default.
• W2126456230 hasConceptScore W2126456230C143065580 @default.
• W2126456230 hasConceptScore W2126456230C151872237 @default.
• W2126456230 hasConceptScore W2126456230C18903297 @default.
• W2126456230 hasConceptScore W2126456230C54355233 @default.
• W2126456230 hasConceptScore W2126456230C54458228 @default.
• W2126456230 hasConceptScore W2126456230C64962909 @default.
• W2126456230 hasConceptScore W2126456230C67705224 @default.
• W2126456230 hasConceptScore W2126456230C86803240 @default.
• W2126456230 hasConceptScore W2126456230C94671646 @default.
• W2126456230 hasConceptScore W2126456230C95444343 @default.
• W2126456230 hasIssue "23" @default.
• W2126456230 hasLocation W21264562301 @default.
• W2126456230 hasLocation W21264562302 @default.
• W2126456230 hasLocation W21264562303 @default.

• next