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- W2126462071 abstract "Fat malabsorption in pancreatic insufficient cystic fibrosis (CF) patients is classically treated with pancreatic enzyme replacement therapy (PERT). Despite PERT, intestinal fat absorption remains insufficient in most CF patients. Several factors have been suggested to contribute to the persistent fat malabsorption in CF (CFPFM). We reviewed the current insights concerning the proposed causes of CFPFM and the corresponding intervention studies. Most data are obtained from studies in CF patients and CF mice. Based on the reviewed literature, we conclude that alterations in intestinal pH and intestinal mucosal abnormalities are most likely to contribute to CFPFM. The presently available data indicate that acid suppressive drugs and broad spectrum antibiotics could be helpful in individual CF patients for optimizing fat absorption and/or nutritional status." @default.
- W2126462071 created "2016-06-24" @default.
- W2126462071 creator A5031718124 @default.
- W2126462071 creator A5047047293 @default.
- W2126462071 creator A5087129912 @default.
- W2126462071 date "2011-05-01" @default.
- W2126462071 modified "2023-10-05" @default.
- W2126462071 title "Persistent fat malabsorption in cystic fibrosis; lessons from patients and mice" @default.
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- W2126462071 doi "https://doi.org/10.1016/j.jcf.2011.03.008" @default.
- W2126462071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21459688" @default.
- W2126462071 hasPublicationYear "2011" @default.
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