FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2126483313> ?p ?o ?g. }

• W2126483313 endingPage "4359" @default.
• W2126483313 startingPage "4345" @default.
• W2126483313 abstract "Matrix metalloproteinases (MMPs) are a group of extracellular proteases involved in tissue remodeling in several physiological and pathophysiological conditions. While increased expression of MMPs (especially MMP-9) has been observed in skeletal muscle in numerous conditions, their physiological significance remains less-well understood. By generating novel skeletal muscle-specific transgenic (Tg) mice expressing constitutively active mutant of MMP-9 (i.e. MMP-9G100L), in this study, we have investigated the effects of elevated levels of MMP-9 on skeletal muscle structure and function in vivo. Tg expression of enzymatically active MMP-9 protein significantly increased skeletal muscle fiber cross-section area, levels of contractile proteins and force production in isometric contractions. MMP-9 stimulated the activation of the Akt signaling pathway in Tg mice. Moreover, expression of active MMP-9 increased the proportion of fast-type fiber in soleus muscle of mice. Overexpression of MMP-9 also considerably reduced the deposition of collagens I and IV in skeletal muscle in vivo. In one-year-old mdx mice (a model for Duchenne muscular dystrophy, DMD), deletion of the Mmp9 gene reduced fiber hypertrophy and phosphorylation of Akt and p38 mitogen-activated protein kinase. Collectively, our study suggests that elevated levels of active MMP-9 protein cause hypertrophy in skeletal muscle and that the modulation of MMP-9 levels may have therapeutic value in various muscular disorders including DMD." @default.
• W2126483313 created "2016-06-24" @default.
• W2126483313 creator A5000895178 @default.
• W2126483313 creator A5003712995 @default.
• W2126483313 creator A5008176171 @default.
• W2126483313 creator A5061594246 @default.
• W2126483313 creator A5067056275 @default.
• W2126483313 creator A5074350735 @default.
• W2126483313 creator A5075094824 @default.
• W2126483313 date "2011-08-16" @default.
• W2126483313 modified "2023-09-23" @default.
• W2126483313 title "Elevated levels of active matrix metalloproteinase-9 cause hypertrophy in skeletal muscle of normal and dystrophin-deficient mdx mice" @default.
• W2126483313 cites W1527845641 @default.
• W2126483313 cites W1530473805 @default.
• W2126483313 cites W1549570910 @default.
• W2126483313 cites W1550326058 @default.
• W2126483313 cites W1580647893 @default.
• W2126483313 cites W1586159393 @default.
• W2126483313 cites W1588947274 @default.
• W2126483313 cites W1963655929 @default.
• W2126483313 cites W1967544564 @default.
• W2126483313 cites W1971857747 @default.
• W2126483313 cites W1979044641 @default.
• W2126483313 cites W1983366269 @default.
• W2126483313 cites W1988393390 @default.
• W2126483313 cites W1994787439 @default.
• W2126483313 cites W1995949259 @default.
• W2126483313 cites W2000792793 @default.
• W2126483313 cites W2000983409 @default.
• W2126483313 cites W2003649729 @default.
• W2126483313 cites W2003708679 @default.
• W2126483313 cites W2006311087 @default.
• W2126483313 cites W2006384404 @default.
• W2126483313 cites W2010777047 @default.
• W2126483313 cites W2013648458 @default.
• W2126483313 cites W2017429680 @default.
• W2126483313 cites W2017504550 @default.
• W2126483313 cites W2025922826 @default.
• W2126483313 cites W2027086778 @default.
• W2126483313 cites W2029816532 @default.
• W2126483313 cites W2030590452 @default.
• W2126483313 cites W2030653802 @default.
• W2126483313 cites W2030776545 @default.
• W2126483313 cites W2032754875 @default.
• W2126483313 cites W2035637866 @default.
• W2126483313 cites W2041244163 @default.
• W2126483313 cites W2053043355 @default.
• W2126483313 cites W2054753294 @default.
• W2126483313 cites W2062867597 @default.
• W2126483313 cites W2071359561 @default.
• W2126483313 cites W2072088562 @default.
• W2126483313 cites W2073357074 @default.
• W2126483313 cites W2075303668 @default.
• W2126483313 cites W2078192607 @default.
• W2126483313 cites W2081305406 @default.
• W2126483313 cites W2083018473 @default.
• W2126483313 cites W2098874403 @default.
• W2126483313 cites W2103773574 @default.
• W2126483313 cites W2112387411 @default.
• W2126483313 cites W2112513572 @default.
• W2126483313 cites W2113145367 @default.
• W2126483313 cites W2115438428 @default.
• W2126483313 cites W2123639616 @default.
• W2126483313 cites W2123919483 @default.
• W2126483313 cites W2124894661 @default.
• W2126483313 cites W2126792732 @default.
• W2126483313 cites W2130917145 @default.
• W2126483313 cites W2131466509 @default.
• W2126483313 cites W2135124706 @default.
• W2126483313 cites W2136799979 @default.
• W2126483313 cites W2141725752 @default.
• W2126483313 cites W2144922436 @default.
• W2126483313 cites W2152710709 @default.
• W2126483313 cites W2153445234 @default.
• W2126483313 cites W2154041187 @default.
• W2126483313 cites W2154326737 @default.
• W2126483313 cites W2161968092 @default.
• W2126483313 cites W2162639406 @default.
• W2126483313 cites W2167709602 @default.
• W2126483313 cites W2168631516 @default.
• W2126483313 cites W2170719580 @default.
• W2126483313 cites W2171324004 @default.
• W2126483313 cites W2187195351 @default.
• W2126483313 cites W4248695876 @default.
• W2126483313 doi "https://doi.org/10.1093/hmg/ddr362" @default.
• W2126483313 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3196885" @default.
• W2126483313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21846793" @default.
• W2126483313 hasPublicationYear "2011" @default.
• W2126483313 type Work @default.
• W2126483313 sameAs 2126483313 @default.
• W2126483313 citedByCount "60" @default.
• W2126483313 countsByYear W21264833132012 @default.
• W2126483313 countsByYear W21264833132013 @default.
• W2126483313 countsByYear W21264833132014 @default.
• W2126483313 countsByYear W21264833132015 @default.
• W2126483313 countsByYear W21264833132016 @default.
• W2126483313 countsByYear W21264833132017 @default.
• W2126483313 countsByYear W21264833132018 @default.

• next