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• W2126502127 endingPage "1969" @default.
• W2126502127 startingPage "1962" @default.
• W2126502127 abstract "ABSTRACT The azomethine‐based oligomers bearing boronate groups and imine moieties in the main chain were synthesized from a dialdehyde monomer and an aromatic (oligomer 4 ) diamine or an aliphatic diamine (oligomer 5 ). Based on the oligomers, the nanoparticles with hydrogen peroxide (H 2 O 2 ) and pH dual‐responsive properties were constructed and encapsulated nile red inside. The nanoparticles disassembled either by the trigger of H 2 O 2 or by the attack of H + , thus leading to the release of loaded species. Compared to oligomer 4 , oligomer 5 showed a faster degradation rate in the presence of H 2 O 2 , especially in a weak acidic environment. No significant cytotoxicity was observed as HeLa cells incubated in the nanoparticles with the concentration up to 200 μg/mL evidenced by cytotoxicity assay in vitro . Such a system capable of dual response of H 2 O 2 and H + may have potential application as a carrier for drug delivery. © 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2014 , 52 , 1962–1969" @default.
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• W2126502127 date "2014-04-22" @default.
• W2126502127 modified "2023-10-05" @default.
• W2126502127 title "Self-immolative nanoparticles triggered by hydrogen peroxide and pH" @default.
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• W2126502127 doi "https://doi.org/10.1002/pola.27203" @default.
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