FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2126524937> ?p ?o ?g. }

• W2126524937 endingPage "164" @default.
• W2126524937 startingPage "155" @default.
• W2126524937 abstract "Keratinocytes synthesize urokinase-type plasminogen activator (uPA) and a specific cell surface receptor for uPA (uPA-R, CD 87). Plasminogen is present in plasma and interstitial fluids from where it is bound to cell surfaces via plasmin(ogen) binding sites. uPA binds to the uPA-R in an autocrine manner and activates cell-bound plasminogen: a mechanism, which provides plasmin for pericellular proteolysis. Cell-bound uPA is regulated by plasminogen activator inhibitor type-1 (PAI-1) or type-2 (PAI-2). Bullous pemphigoid is an autoimmune inflammatory skin disease characterized by subepidermal blisters. Although circumstantial evidence suggested plasminogen activation in lesional epidermis of bullous pemphigoid, immunohistological data on the type of plasminogen activators, on the uPA-receptor or the type of plasminogen activator inhibitors in the lesions of bullous pemphigoid are lacking so far. To obtain this information we have performed the present immunohistological study. The presence of uPA and its receptor as well as PAI-2 was disclosed in epidermal keratinocytes in the roof of the subepidermal blisters. Moreover, keratinocytes at the bottom of the blister, which most likely represent keratinocytes during reepithelialization were stained. Co-localization was found for uPA and its receptor, uPA and plasmin(ogen) as well as for uPA and PAI-2. In non-lesional epidermis of bullous pemphigoid only PAI-2 was found. We propose that the expression of uPA and uPA-R, as well as the upregulation of PAI-2 in keratinocytes of lesional epidermis is part of the repair and reepithelialization process following lesion formation, i.e. epidermo-dermal dyshesion, in bullous pemphigoid." @default.
• W2126524937 created "2016-06-24" @default.
• W2126524937 creator A5053902768 @default.
• W2126524937 creator A5065755668 @default.
• W2126524937 creator A5075378797 @default.
• W2126524937 creator A5075912422 @default.
• W2126524937 date "1996-01-01" @default.
• W2126524937 modified "2023-09-23" @default.
• W2126524937 title "Plasminogen Activation in Bullous Pemphigoid Immunohistology Reveals Urokinase Type Plasminogen Activator, Its Receptor and Plasminogen Activator Inhibitor Type-2 in Lesional Epidermis" @default.
• W2126524937 cites W1604744894 @default.
• W2126524937 cites W1967647746 @default.
• W2126524937 cites W1980545776 @default.
• W2126524937 cites W1986343743 @default.
• W2126524937 cites W1989170373 @default.
• W2126524937 cites W1992947181 @default.
• W2126524937 cites W2013077332 @default.
• W2126524937 cites W2016450706 @default.
• W2126524937 cites W2017940362 @default.
• W2126524937 cites W2021245965 @default.
• W2126524937 cites W2022337796 @default.
• W2126524937 cites W2025100434 @default.
• W2126524937 cites W2044665644 @default.
• W2126524937 cites W2050033308 @default.
• W2126524937 cites W2050148011 @default.
• W2126524937 cites W2056603893 @default.
• W2126524937 cites W2057770248 @default.
• W2126524937 cites W2067459429 @default.
• W2126524937 cites W2082478113 @default.
• W2126524937 cites W2087683866 @default.
• W2126524937 cites W2088738897 @default.
• W2126524937 cites W2125898415 @default.
• W2126524937 cites W2127658072 @default.
• W2126524937 cites W2151328845 @default.
• W2126524937 cites W2154671319 @default.
• W2126524937 cites W2166269635 @default.
• W2126524937 cites W38263071 @default.
• W2126524937 cites W4234881113 @default.
• W2126524937 doi "https://doi.org/10.3109/08916939608995339" @default.
• W2126524937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8879451" @default.
• W2126524937 hasPublicationYear "1996" @default.
• W2126524937 type Work @default.
• W2126524937 sameAs 2126524937 @default.
• W2126524937 citedByCount "7" @default.
• W2126524937 countsByYear W21265249372016 @default.
• W2126524937 crossrefType "journal-article" @default.
• W2126524937 hasAuthorship W2126524937A5053902768 @default.
• W2126524937 hasAuthorship W2126524937A5065755668 @default.
• W2126524937 hasAuthorship W2126524937A5075378797 @default.
• W2126524937 hasAuthorship W2126524937A5075912422 @default.
• W2126524937 hasConcept C105702510 @default.
• W2126524937 hasConcept C126322002 @default.
• W2126524937 hasConcept C134018914 @default.
• W2126524937 hasConcept C142724271 @default.
• W2126524937 hasConcept C153911025 @default.
• W2126524937 hasConcept C159654299 @default.
• W2126524937 hasConcept C170493617 @default.
• W2126524937 hasConcept C181199279 @default.
• W2126524937 hasConcept C185592680 @default.
• W2126524937 hasConcept C202751555 @default.
• W2126524937 hasConcept C203014093 @default.
• W2126524937 hasConcept C2776458125 @default.
• W2126524937 hasConcept C2776892390 @default.
• W2126524937 hasConcept C2777074287 @default.
• W2126524937 hasConcept C2778075117 @default.
• W2126524937 hasConcept C2779252107 @default.
• W2126524937 hasConcept C2779679481 @default.
• W2126524937 hasConcept C2780675426 @default.
• W2126524937 hasConcept C2781071845 @default.
• W2126524937 hasConcept C502942594 @default.
• W2126524937 hasConcept C55493867 @default.
• W2126524937 hasConcept C56219504 @default.
• W2126524937 hasConcept C71924100 @default.
• W2126524937 hasConcept C86803240 @default.
• W2126524937 hasConceptScore W2126524937C105702510 @default.
• W2126524937 hasConceptScore W2126524937C126322002 @default.
• W2126524937 hasConceptScore W2126524937C134018914 @default.
• W2126524937 hasConceptScore W2126524937C142724271 @default.
• W2126524937 hasConceptScore W2126524937C153911025 @default.
• W2126524937 hasConceptScore W2126524937C159654299 @default.
• W2126524937 hasConceptScore W2126524937C170493617 @default.
• W2126524937 hasConceptScore W2126524937C181199279 @default.
• W2126524937 hasConceptScore W2126524937C185592680 @default.
• W2126524937 hasConceptScore W2126524937C202751555 @default.
• W2126524937 hasConceptScore W2126524937C203014093 @default.
• W2126524937 hasConceptScore W2126524937C2776458125 @default.
• W2126524937 hasConceptScore W2126524937C2776892390 @default.
• W2126524937 hasConceptScore W2126524937C2777074287 @default.
• W2126524937 hasConceptScore W2126524937C2778075117 @default.
• W2126524937 hasConceptScore W2126524937C2779252107 @default.
• W2126524937 hasConceptScore W2126524937C2779679481 @default.
• W2126524937 hasConceptScore W2126524937C2780675426 @default.
• W2126524937 hasConceptScore W2126524937C2781071845 @default.
• W2126524937 hasConceptScore W2126524937C502942594 @default.
• W2126524937 hasConceptScore W2126524937C55493867 @default.
• W2126524937 hasConceptScore W2126524937C56219504 @default.
• W2126524937 hasConceptScore W2126524937C71924100 @default.
• W2126524937 hasConceptScore W2126524937C86803240 @default.
• W2126524937 hasIssue "3" @default.

• next