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• W2126531486 abstract "No AccessJournal of UrologyClinical Urology: Original Article1 Mar 1999AMMONIUM ACID URATE CALCULI: A REEVALUATION OF RISK FACTORS JON J. SOBLE, BLAKE D. HAMILTON, and STEVAN B. STREEM JON J. SOBLEJON J. SOBLE More articles by this author , BLAKE D. HAMILTONBLAKE D. HAMILTON More articles by this author , and STEVAN B. STREEMSTEVAN B. STREEM More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)61794-4AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We reevaluate the demographic and metabolic risk factors for ammonium acid urate stones. Materials and Methods: Since 1986, 23 women and 21 men ranging in age from 20 to 81 years (mean 48.7) were treated for stones partly composed of ammonium acid urate. Stone composition ranged from 2 to 60% ammonium acid urate (mean 24.1) of the total stone mass. No patient had a pure ammonium acid urate stone, although 11 (25%) had stones with ammonium acid urate as the predominant crystal. Results: In the 44 patients 1 or more potential risk factors for ammonium acid urate were identified. Of the patients 11 (25%) had a history of inflammatory bowel disease with 10 (22.7%) having undergone ileostomy diversion, 6 (13.6%) admitted to a history of significant laxative use or abuse, 18 (40.9%) were morbidly obese, 16 (36.4%) had a history of recurrent urinary tract infections and 9 (20.5%) had a history of recurrent uric acid stones. Conclusions: Patients clearly at risk for stones with an ammonium acid urate component include those with a history of inflammatory bowel disease and ileostomy diversion or laxative abuse. Other factors that may potentially enhance ammonium acid urate stone formation include morbid obesity, recurrent uric acid calculi and recurrent urinary tract infection. A careful history followed by further metabolic evaluation is warranted in these patients. References 1 : Mineral composition of 103 stones from Iran. Brit. J. Urol.1983; 55: 465. Google Scholar 2 : Childhood urolithiasis in Iran: a comparative study on the calculi composition of 121 cases. Zeitschrift fur Kinderchirurgie1985; 40: 163. Google Scholar 3 : Childhood urolithiasis in Iran with special reference to staghorn calculi. Urol. Int.1990; 45: 99. Crossref, Medline, Google Scholar 4 : Infrared spectrometric analysis of endemic bladder stones in Niger. Eur. Urol.1995; 27: 154. Google Scholar 5 : Ammonium acid urate stones in Navajo Indian children. Urology1979; 14: 9. Google Scholar 6 : Ammonium urate urinary stones. Urol. Res.1986; 14: 315. Google Scholar 7 : Urolithiasis related to laxative abuse. J. Form. Med. Assn.1993; 92: 1004. Google Scholar 8 : [Urolithiasis in children in West Algeria]. Ann. Urol.1997; 31: 84. 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Google Scholar 17 : The extra-intestinal complications of Crohn's disease and ulcerative colitis: a study of 700 patients. Medicine1976; 55: 401. Google Scholar 18 : Urolithiasis and hyperoxaluria in chronic inflammatory bowel disease. Scand. J. Gastroenterol.1979; 14: 475. Google Scholar 19 : Urolithiasis in chronic inflammatory bowel disease. Scand. J. Gastroenterol.1978; 13: 433. Google Scholar 20 : Comparison of relative risks of urinary stone formation after surgery for ulcerative colitis: conventional ileostomy vs J-pouch. A comparative study. . Dis. Colon Rectum1996; 39: 50. Google Scholar 21 : Importance of the colon in enteric hyperoxaluria. New Engl. J. Med.1977; 296: 298. Google Scholar 22 : Factors affecting the solubility of ammonium acid urate. Clin. Chem. Acta1979; 95: 17. Google Scholar 23 : Obesity and urinary stone disease. J. Endourol.1997; 11: S150. Google Scholar From the Department of Urology, Cleveland Clinic Foundation, Cleveland, Ohio(SOBLE) Current address: Section of Urology, Weiss Hospital, University of Chicago, 4646 N. Marine Drive, Chicago, Illinois 60640.(HAMILTON) Current address: Division of Urology, University of Utah, 50 N. Medical Drive, Salt Lake City, Utah 84132.(STREEM) Requests for reprints: Department of Urology, Cleveland Clinic Foundation, 9500 Euclid Ave. A100, Cleveland, Ohio 44195.© 1999 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byAssimos D (2020) Re: Nephrolithiasis and Elevated Urinary Ammonium: A Matched Comparative StudyJournal of Urology, VOL. 204, NO. 5, (1090-1090), Online publication date: 1-Nov-2020.Assimos D (2018) Re: Composition of Urinary Calculi in Infants: A Report from an Endemic CountryJournal of Urology, VOL. 199, NO. 5, (1105-1107), Online publication date: 1-May-2018.Smith C, Poindexter J, Meegan J, Bobulescu I, Jensen E, Venn-Watson S and Sakhaee K (2014) Pathophysiological and Physicochemical Basis of Ammonium Urate Stone Formation in DolphinsJournal of Urology, VOL. 192, NO. 1, (260-266), Online publication date: 1-Jul-2014.Gabrielsen J, Laciak R, Frank E, McFadden M, Bates C, Oottamasathien S, Hamilton B and Wallis M (2012) Pediatric Urinary Stone Composition in the United StatesJournal of Urology, VOL. 187, NO. 6, (2182-2187), Online publication date: 1-Jun-2012. Volume 161Issue 3March 1999Page: 869-873 Advertisement Copyright & Permissions© 1999 by American Urological Association, Inc.MetricsAuthor Information JON J. SOBLE More articles by this author BLAKE D. HAMILTON More articles by this author STEVAN B. STREEM More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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