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- W2126542457 abstract "A NGIOIMMUNOBLASTIC lymphadenopathy (AIL) is a non-neoplastic, proliferative disorder of lymphocytes characterized clinically by fever, generalized lymphadenopathy, hepatosplenomegaly, skin rash, polyclonal hypergammaglobulinemia, and frequently, Coombs positive hemolytic anemia. Histologically, normal lymph node architecture is distorted by a lymphoplasmacytic infiltrate, accompanied by finely arborizing blood vessels and often by the interstitial deposition of an amorphous eosinophilic material.“2 There are many similarities between AIL and connective tissue disease, especially systemic lupus erythematosus (SLE). That these conditions can exhibit similar clinical manifestations and pathogenic mechanisms has been noted in the literature. jV4 For example, the presence of various autoantibodies, including ANA, has been documented in AIL.‘-” On the other hand, we have been able to find only two cases in which clinical AIL and SLE seemed to have occurred simultaneously.8~‘3 By contrast, our patient had longstanding connective tissue disease, starting as mixed connective tissue disease (MCTD) which evolved into classical SLE, and ultimately died from AIL. The unusual nature of this case prompted us to review the association of SLE to AIL." @default.
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- W2126542457 date "1986-11-01" @default.
- W2126542457 modified "2023-10-16" @default.
- W2126542457 title "Systemic lupus erythematosus and angioimmunoblastic lymphadenopathy: Case report and review of the literature" @default.
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- W2126542457 doi "https://doi.org/10.1016/0049-0172(86)90048-x" @default.
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