Matches in SemOpenAlex for { <https://semopenalex.org/work/W2126544457> ?p ?o ?g. }
- W2126544457 endingPage "1084" @default.
- W2126544457 startingPage "1079" @default.
- W2126544457 abstract "The combined action of cholera toxin (CT)-dependent activation of the adenylate cyclase signaling pathway, stimulation of protein kinase C, and activation of the tyrosine kinase activity of cell surface receptors and proto-oncogene products, have been shown to stimulate melanocyte proliferation. However, natural factors responsible for the optimal stimulation of normal human melanocyte growth, either isolated or co-cultured with keratinocytes, remain largely unknown. alpha MSH (alpha melanocyte stimulating hormone) has previously been shown to bind to murine and human melanoma cells and to stimulate their adenylate cyclase and tyrosinase activity. In contrast, very little is known about the presence and function of alpha MSH receptors in normal human melanocytes. We now report that alpha MSH: (i) binds to normal human melanocytes through a single class of high-affinity receptors; (ii) does not induce per se melanocytes to enter the S-phase of the cell cycle; (iii) does indeed stimulate melanocyte proliferation in a dose-dependent fashion; but its stimulatory effect requires bFGF and/or the activation of protein kinase C." @default.
- W2126544457 created "2016-06-24" @default.
- W2126544457 creator A5017571232 @default.
- W2126544457 creator A5025191282 @default.
- W2126544457 creator A5036347819 @default.
- W2126544457 creator A5041339142 @default.
- W2126544457 creator A5050032670 @default.
- W2126544457 creator A5078282667 @default.
- W2126544457 date "1993-08-01" @default.
- W2126544457 modified "2023-10-09" @default.
- W2126544457 title "α Melanocyte stimulating hormone (αmsh) stimulates normal human melanocyte growth by binding to high-affinity receptors" @default.
- W2126544457 cites W1519510465 @default.
- W2126544457 cites W1549618031 @default.
- W2126544457 cites W1555297725 @default.
- W2126544457 cites W1926874813 @default.
- W2126544457 cites W1976403250 @default.
- W2126544457 cites W2020865252 @default.
- W2126544457 cites W2038986705 @default.
- W2126544457 cites W2039403395 @default.
- W2126544457 cites W2042629233 @default.
- W2126544457 cites W2043813981 @default.
- W2126544457 cites W2048747800 @default.
- W2126544457 cites W2056219779 @default.
- W2126544457 cites W2058633253 @default.
- W2126544457 cites W2059287983 @default.
- W2126544457 cites W2061867074 @default.
- W2126544457 cites W2071439612 @default.
- W2126544457 cites W2074869094 @default.
- W2126544457 cites W2108060319 @default.
- W2126544457 cites W2114547725 @default.
- W2126544457 cites W2114941600 @default.
- W2126544457 cites W2131326834 @default.
- W2126544457 cites W2168009612 @default.
- W2126544457 cites W2170789806 @default.
- W2126544457 cites W2330471367 @default.
- W2126544457 cites W2428242608 @default.
- W2126544457 doi "https://doi.org/10.1242/jcs.105.4.1079" @default.
- W2126544457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8227196" @default.
- W2126544457 hasPublicationYear "1993" @default.
- W2126544457 type Work @default.
- W2126544457 sameAs 2126544457 @default.
- W2126544457 citedByCount "88" @default.
- W2126544457 countsByYear W21265444572012 @default.
- W2126544457 countsByYear W21265444572013 @default.
- W2126544457 countsByYear W21265444572014 @default.
- W2126544457 countsByYear W21265444572015 @default.
- W2126544457 countsByYear W21265444572016 @default.
- W2126544457 countsByYear W21265444572017 @default.
- W2126544457 countsByYear W21265444572018 @default.
- W2126544457 countsByYear W21265444572019 @default.
- W2126544457 countsByYear W21265444572021 @default.
- W2126544457 countsByYear W21265444572022 @default.
- W2126544457 countsByYear W21265444572023 @default.
- W2126544457 crossrefType "journal-article" @default.
- W2126544457 hasAuthorship W2126544457A5017571232 @default.
- W2126544457 hasAuthorship W2126544457A5025191282 @default.
- W2126544457 hasAuthorship W2126544457A5036347819 @default.
- W2126544457 hasAuthorship W2126544457A5041339142 @default.
- W2126544457 hasAuthorship W2126544457A5050032670 @default.
- W2126544457 hasAuthorship W2126544457A5078282667 @default.
- W2126544457 hasConcept C126322002 @default.
- W2126544457 hasConcept C134018914 @default.
- W2126544457 hasConcept C170493617 @default.
- W2126544457 hasConcept C180526460 @default.
- W2126544457 hasConcept C197462201 @default.
- W2126544457 hasConcept C2777658100 @default.
- W2126544457 hasConcept C2779769559 @default.
- W2126544457 hasConcept C2780989459 @default.
- W2126544457 hasConcept C502942594 @default.
- W2126544457 hasConcept C55493867 @default.
- W2126544457 hasConcept C62478195 @default.
- W2126544457 hasConcept C71924100 @default.
- W2126544457 hasConcept C86803240 @default.
- W2126544457 hasConcept C95444343 @default.
- W2126544457 hasConceptScore W2126544457C126322002 @default.
- W2126544457 hasConceptScore W2126544457C134018914 @default.
- W2126544457 hasConceptScore W2126544457C170493617 @default.
- W2126544457 hasConceptScore W2126544457C180526460 @default.
- W2126544457 hasConceptScore W2126544457C197462201 @default.
- W2126544457 hasConceptScore W2126544457C2777658100 @default.
- W2126544457 hasConceptScore W2126544457C2779769559 @default.
- W2126544457 hasConceptScore W2126544457C2780989459 @default.
- W2126544457 hasConceptScore W2126544457C502942594 @default.
- W2126544457 hasConceptScore W2126544457C55493867 @default.
- W2126544457 hasConceptScore W2126544457C62478195 @default.
- W2126544457 hasConceptScore W2126544457C71924100 @default.
- W2126544457 hasConceptScore W2126544457C86803240 @default.
- W2126544457 hasConceptScore W2126544457C95444343 @default.
- W2126544457 hasIssue "4" @default.
- W2126544457 hasLocation W21265444571 @default.
- W2126544457 hasLocation W21265444572 @default.
- W2126544457 hasOpenAccess W2126544457 @default.
- W2126544457 hasPrimaryLocation W21265444571 @default.
- W2126544457 hasRelatedWork W2022904829 @default.
- W2126544457 hasRelatedWork W2026337347 @default.
- W2126544457 hasRelatedWork W2026496827 @default.
- W2126544457 hasRelatedWork W2083336760 @default.
- W2126544457 hasRelatedWork W2090575027 @default.