FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2126564307> ?p ?o ?g. }

• W2126564307 endingPage "77" @default.
• W2126564307 startingPage "65" @default.
• W2126564307 abstract "Associations between plasma membrane-linked proteins and the actin cytoskeleton play a crucial role in defining cell shape and determination, ensuring cell motility and facilitating cell-cell or cell-substratum adhesion. Here, we present evidence that CEACAM1-L, a cell adhesion molecule of the carcinoembryonic antigen family, is associated with the actin cytoskeleton. We have delineated the regions involved in actin cytoskeleton association to the distal end of the CEACAM1-L long cytoplasmic domain. We have demonstrated that CEACAM1-S, an isoform of CEACAM1 with a truncated cytoplasmic domain, does not interact with the actin cytoskeleton. In addition, a major difference in subcellular localization of the two CEACAM1 isoforms was observed. Furthermore, we have established that the localization of CEACAM1-L at cell-cell boundaries is regulated by the Rho family of GTPases. The retention of the protein at the sites of intercellular contacts critically depends on homophilic CEACAM1-CEACAM1 interactions and association with the actin cytoskeleton. Our results provide new evidence on how the Rho family of GTPases can control cell adhesion: by directing an adhesion molecule to its proper cellular destination. In addition, these results provide an insight into the mechanisms of why CEACAM1-L, but not CEACAM1-S, functions as a tumor cell growth inhibitor." @default.
• W2126564307 created "2016-06-24" @default.
• W2126564307 creator A5003792093 @default.
• W2126564307 creator A5032396875 @default.
• W2126564307 creator A5051844715 @default.
• W2126564307 creator A5079233521 @default.
• W2126564307 date "2000-01-01" @default.
• W2126564307 modified "2023-10-13" @default.
• W2126564307 title "The CEACAM1-L Glycoprotein Associates with the Actin Cytoskeleton and Localizes to Cell–Cell Contact through Activation of Rho-like GTPases" @default.
• W2126564307 cites W1277151639 @default.
• W2126564307 cites W1436413411 @default.
• W2126564307 cites W1484706216 @default.
• W2126564307 cites W1494237198 @default.
• W2126564307 cites W1515025801 @default.
• W2126564307 cites W1522333577 @default.
• W2126564307 cites W153332747 @default.
• W2126564307 cites W1538303836 @default.
• W2126564307 cites W1563354863 @default.
• W2126564307 cites W1567784860 @default.
• W2126564307 cites W1631351130 @default.
• W2126564307 cites W1826861972 @default.
• W2126564307 cites W1865235773 @default.
• W2126564307 cites W1964925886 @default.
• W2126564307 cites W1967265143 @default.
• W2126564307 cites W1980295525 @default.
• W2126564307 cites W1981752846 @default.
• W2126564307 cites W1983462117 @default.
• W2126564307 cites W1988078820 @default.
• W2126564307 cites W1992449776 @default.
• W2126564307 cites W1996404678 @default.
• W2126564307 cites W2002410732 @default.
• W2126564307 cites W2006506188 @default.
• W2126564307 cites W2013514411 @default.
• W2126564307 cites W2014386327 @default.
• W2126564307 cites W2015033011 @default.
• W2126564307 cites W2021766527 @default.
• W2126564307 cites W2022487668 @default.
• W2126564307 cites W2027810531 @default.
• W2126564307 cites W2036145275 @default.
• W2126564307 cites W2040519526 @default.
• W2126564307 cites W2043527956 @default.
• W2126564307 cites W2044172471 @default.
• W2126564307 cites W2053190811 @default.
• W2126564307 cites W2054037411 @default.
• W2126564307 cites W2062158697 @default.
• W2126564307 cites W2066058356 @default.
• W2126564307 cites W2066367871 @default.
• W2126564307 cites W2068183558 @default.
• W2126564307 cites W2071896162 @default.
• W2126564307 cites W2073597369 @default.
• W2126564307 cites W2076337034 @default.
• W2126564307 cites W2077792958 @default.
• W2126564307 cites W2080510429 @default.
• W2126564307 cites W2084012699 @default.
• W2126564307 cites W2086121244 @default.
• W2126564307 cites W2088618181 @default.
• W2126564307 cites W2093226717 @default.
• W2126564307 cites W2095359507 @default.
• W2126564307 cites W2096796084 @default.
• W2126564307 cites W2101480539 @default.
• W2126564307 cites W2102986711 @default.
• W2126564307 cites W2107739798 @default.
• W2126564307 cites W2119632652 @default.
• W2126564307 cites W2122218045 @default.
• W2126564307 cites W2128938673 @default.
• W2126564307 cites W2131447123 @default.
• W2126564307 cites W2134073082 @default.
• W2126564307 cites W2134547554 @default.
• W2126564307 cites W2135977869 @default.
• W2126564307 cites W2139242459 @default.
• W2126564307 cites W2141535066 @default.
• W2126564307 cites W2143124350 @default.
• W2126564307 cites W2148380254 @default.
• W2126564307 cites W2152731523 @default.
• W2126564307 cites W2155723996 @default.
• W2126564307 cites W2164973413 @default.
• W2126564307 cites W2166241889 @default.
• W2126564307 cites W2169019804 @default.
• W2126564307 cites W2172069309 @default.
• W2126564307 cites W2172069484 @default.
• W2126564307 cites W2172160601 @default.
• W2126564307 cites W2176511881 @default.
• W2126564307 cites W2185424976 @default.
• W2126564307 cites W2273092316 @default.
• W2126564307 cites W2280885574 @default.
• W2126564307 cites W2319853571 @default.
• W2126564307 cites W2399703409 @default.
• W2126564307 cites W2399948064 @default.
• W2126564307 cites W2426157868 @default.
• W2126564307 cites W268479530 @default.
• W2126564307 cites W4231743681 @default.
• W2126564307 cites W4250102918 @default.
• W2126564307 doi "https://doi.org/10.1091/mbc.11.1.65" @default.
• W2126564307 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/14757" @default.
• W2126564307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10637291" @default.
• W2126564307 hasPublicationYear "2000" @default.
• W2126564307 type Work @default.
• W2126564307 sameAs 2126564307 @default.

• next