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- W2126565462 abstract "LSm1-7 complexes promote cellular mRNA degradation, in addition to translation and replication of positive-strand RNA viruses such as the Brome mosaic virus (BMV). Yet, how LSm1-7 complexes act on their targets remains elusive. Here, we report that reconstituted recombinant LSm1-7 complexes directly bind to two distinct RNA-target sequences in the BMV genome, a tRNA-like structure at the 3′-untranslated region and two internal A-rich single-stranded regions. Importantly, in vivo analysis shows that these sequences regulate the translation and replication of the BMV genome. Furthermore, both RNA-target sequences resemble those found for Hfq, the LSm counterpart in bacteria, suggesting conservation through evolution. Our results provide the first evidence that LSm1-7 complexes interact directly with viral RNA genomes and open new perspectives in the understanding of LSm1-7 functions." @default.
- W2126565462 created "2016-06-24" @default.
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- W2126565462 date "2010-02-24" @default.
- W2126565462 modified "2023-10-15" @default.
- W2126565462 title "LSm1-7 complexes bind to specific sites in viral RNA genomes and regulate their translation and replication" @default.
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- W2126565462 doi "https://doi.org/10.1261/rna.1712910" @default.
- W2126565462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2844628" @default.
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