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- W2126591750 abstract "Abstract Germination and early seedling establishment are developmental stages in which plants face limited nutrient supply as their photosynthesis mechanism is not yet active. For this reason, the plant must mobilize the nutrient reserves provided by the mother plant in order to facilitate growth. Autophagy is a catabolic process enabling the bulk degradation of cellular constituents in the vacuole. The autophagy mechanism is conserved among eukaryotes, and homologs of many autophagy-related (ATG) genes have been found in Arabidopsis thaliana. T-DNA insertion mutants (atg mutants) of these genes display higher sensitivity to various stresses, particularly nutrient starvation. However, the direct impact of autophagy on cellular metabolism has not been well studied. In this work, we used etiolated Arabidopsis seedlings as a model system for carbon starvation. atg mutant seedlings display delayed growth in response to carbon starvation compared with wild-type seedlings. High-throughput metabolomic, lipidomic, and proteomic analyses were performed, as well as extensive flux analyses, in order to decipher the underlying causes of the phenotype. Significant differences between atg mutants and wild-type plants have been demonstrated, suggesting global effects of autophagy on central metabolism during carbon starvation as well as severe energy deprivation, resulting in a morphological phenotype." @default.
- W2126591750 created "2016-06-24" @default.
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- W2126591750 date "2015-02-01" @default.
- W2126591750 modified "2023-10-17" @default.
- W2126591750 title "Global Analysis of the Role of Autophagy in Cellular Metabolism and Energy Homeostasis in Arabidopsis Seedlings under Carbon Starvation" @default.
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- W2126591750 doi "https://doi.org/10.1105/tpc.114.134205" @default.
- W2126591750 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4456922" @default.
- W2126591750 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25649436" @default.
- W2126591750 hasPublicationYear "2015" @default.
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