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• W2126634778 abstract "Background The reasons for fecal incontinence after surgery for Hirschsprung disease (HD) remain unclear. The aim of this study was to examine the anal sphincters by anal endosonography and manometry after transanal endorectal pull-through, with or without laparotomy or laparoscopy, in HD patients. Furthermore, we aimed to correlate these findings to bowel function. Patients and methods Fifty-two HD patients were followed after endorectal pull-through. Anal endosonography and manometry were performed without sedation at the age of 3 to 16 years. Results Endosonographic internal anal sphincter (IAS) defects were found in 24/50 patients, more frequently after transanal than transabdominal procedures (69 vs. 19%, p = 0.001). In a multiple variable logistic regression model, operative approach was the only significant predictor for IAS defects. Anal resting pressure (median 40 mm Hg, range 15–120) was not correlated to presence of IAS defects. Daily fecal incontinence occurred more often in patients with IAS defects (54 vs. 25%, p = 0.03). Conclusions Postoperative IAS defects were frequently detected and were associated with daily fecal incontinence. IAS defects occurred more often after solely transanal procedures. We propose that these surgical approaches are compared in a randomized controlled trial before solely transanal endorectal pull-through is performed as a routine procedure." @default.
• W2126634778 created "2016-06-24" @default.
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• W2126634778 date "2015-08-01" @default.
• W2126634778 modified "2023-10-05" @default.
• W2126634778 title "Anal endosonography and bowel function in patients undergoing different types of endorectal pull-through procedures for Hirschsprung disease" @default.
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• W2126634778 doi "https://doi.org/10.1016/j.jpedsurg.2014.12.024" @default.
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