FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2126638108> ?p ?o ?g. }

• W2126638108 endingPage "61" @default.
• W2126638108 startingPage "48" @default.
• W2126638108 abstract "The in vivo effects of the intraperitoneal administration of an Urtica urens L. (dwarf nettle) seed extract were examined on the hepatic, pulmonary, and renal cytochrome P450-dependent monooxygenase activities of rats co-administered with 3-methylcholanthrene (MC). Urtica extract was administered by intraperitoneal injection to male Wistar rats at 200 mgkg(-1)day(-1) for 4 days from which were also co-administered with intraperitoneal injection of 50mg of MC kg(-1) of body weight twice on days 1 and 3. MC treatment increased the 7-ethoxyresorufin O-deethylase (EROD) activity of the liver, lung, and kidney 54-, 21-, and 119-fold, respectively. Urtica treatment substantially reduced the 3MC induction of hepatic, lung, and renal EROD activity by 79, 42, and 50%, respectively. Similarly, compared with the control, MROD activities in liver and kidney were increased after MC administration, and these increases were significantly inhibited by Urtica. reverse transcriptase-polymerase chain reaction (RT-PCR) analysis clearly showed that the hepatic CYP1A1 and CYP1A2 mRNA levels substantially increased after treatment with MC, which was suppressed by Urtica supplementation. Western blotting studies also supported the alterations observed in the catalytic activities and mRNA levels. In conclusion, substantial reduction in CYP1A1 and CYP1A2 expression levels and related activities with Urtica are possibly associated with a potential chemoprotective ability of the Urtica due to the anticipated decrease in the activation of environmental chemical carcinogens through modulation of the CYP1A enzymes." @default.
• W2126638108 created "2016-06-24" @default.
• W2126638108 creator A5013712666 @default.
• W2126638108 creator A5016258061 @default.
• W2126638108 creator A5043164446 @default.
• W2126638108 date "2008-01-01" @default.
• W2126638108 modified "2023-10-09" @default.
• W2126638108 title "<i>In vivo</i>effects of<i>Urtica urens</i>(dwarf nettle) on the expression of CYP1A in control and 3-methylcholanthrene-exposed rats" @default.
• W2126638108 cites W1217421906 @default.
• W2126638108 cites W136355807 @default.
• W2126638108 cites W1508536142 @default.
• W2126638108 cites W1530925956 @default.
• W2126638108 cites W1589382058 @default.
• W2126638108 cites W1775749144 @default.
• W2126638108 cites W1806194750 @default.
• W2126638108 cites W1893149856 @default.
• W2126638108 cites W1917370654 @default.
• W2126638108 cites W1974031469 @default.
• W2126638108 cites W1974881916 @default.
• W2126638108 cites W1976659958 @default.
• W2126638108 cites W1977444929 @default.
• W2126638108 cites W1978903243 @default.
• W2126638108 cites W1980998456 @default.
• W2126638108 cites W1984032948 @default.
• W2126638108 cites W1990389064 @default.
• W2126638108 cites W1997048544 @default.
• W2126638108 cites W2002396362 @default.
• W2126638108 cites W2006998778 @default.
• W2126638108 cites W2013455786 @default.
• W2126638108 cites W2026959257 @default.
• W2126638108 cites W2032181761 @default.
• W2126638108 cites W2034834397 @default.
• W2126638108 cites W2043263657 @default.
• W2126638108 cites W2052455513 @default.
• W2126638108 cites W2054178406 @default.
• W2126638108 cites W2059765523 @default.
• W2126638108 cites W2085319127 @default.
• W2126638108 cites W2085380411 @default.
• W2126638108 cites W2089335941 @default.
• W2126638108 cites W2089362925 @default.
• W2126638108 cites W2090239105 @default.
• W2126638108 cites W2091560133 @default.
• W2126638108 cites W2092191147 @default.
• W2126638108 cites W2100837269 @default.
• W2126638108 cites W2101026512 @default.
• W2126638108 cites W2127423538 @default.
• W2126638108 cites W2135536512 @default.
• W2126638108 cites W2137409024 @default.
• W2126638108 cites W2138124824 @default.
• W2126638108 cites W2148012276 @default.
• W2126638108 cites W2166260496 @default.
• W2126638108 cites W2204173622 @default.
• W2126638108 cites W2317321913 @default.
• W2126638108 cites W2409770896 @default.
• W2126638108 cites W61588189 @default.
• W2126638108 doi "https://doi.org/10.1080/00498250701713968" @default.
• W2126638108 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18098063" @default.
• W2126638108 hasPublicationYear "2008" @default.
• W2126638108 type Work @default.
• W2126638108 sameAs 2126638108 @default.
• W2126638108 citedByCount "15" @default.
• W2126638108 countsByYear W21266381082012 @default.
• W2126638108 countsByYear W21266381082014 @default.
• W2126638108 countsByYear W21266381082015 @default.
• W2126638108 countsByYear W21266381082019 @default.
• W2126638108 countsByYear W21266381082020 @default.
• W2126638108 countsByYear W21266381082022 @default.
• W2126638108 crossrefType "journal-article" @default.
• W2126638108 hasAuthorship W2126638108A5013712666 @default.
• W2126638108 hasAuthorship W2126638108A5016258061 @default.
• W2126638108 hasAuthorship W2126638108A5043164446 @default.
• W2126638108 hasConcept C126322002 @default.
• W2126638108 hasConcept C134018914 @default.
• W2126638108 hasConcept C150903083 @default.
• W2126638108 hasConcept C185592680 @default.
• W2126638108 hasConcept C207001950 @default.
• W2126638108 hasConcept C2779964429 @default.
• W2126638108 hasConcept C2780091579 @default.
• W2126638108 hasConcept C2780159080 @default.
• W2126638108 hasConcept C526171541 @default.
• W2126638108 hasConcept C556039675 @default.
• W2126638108 hasConcept C62231903 @default.
• W2126638108 hasConcept C71924100 @default.
• W2126638108 hasConcept C86745063 @default.
• W2126638108 hasConcept C86803240 @default.
• W2126638108 hasConcept C98274493 @default.
• W2126638108 hasConceptScore W2126638108C126322002 @default.
• W2126638108 hasConceptScore W2126638108C134018914 @default.
• W2126638108 hasConceptScore W2126638108C150903083 @default.
• W2126638108 hasConceptScore W2126638108C185592680 @default.
• W2126638108 hasConceptScore W2126638108C207001950 @default.
• W2126638108 hasConceptScore W2126638108C2779964429 @default.
• W2126638108 hasConceptScore W2126638108C2780091579 @default.
• W2126638108 hasConceptScore W2126638108C2780159080 @default.
• W2126638108 hasConceptScore W2126638108C526171541 @default.
• W2126638108 hasConceptScore W2126638108C556039675 @default.
• W2126638108 hasConceptScore W2126638108C62231903 @default.
• W2126638108 hasConceptScore W2126638108C71924100 @default.

• next