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• W2126658988 endingPage "e3751" @default.
• W2126658988 startingPage "e3751" @default.
• W2126658988 abstract "Numerous serologic tests are available for the diagnosis of H. pylori infection in children. Common designs of antibody-based detection tests are ELISA and Western Blot (WB). For developing countries with limited laboratory resources and access, ELISA would be the preferred method because of its simplicity, lower cost and speed. Although in adults ELISA has proven to be highly accurate in diagnosing H. pylori infection; in children, it has shown variable accuracy.We conducted a systematic review and meta-analysis to assess the accuracy of antibody-based detection tests for the diagnosis of H. pylori infection in children. Selection criteria included participation of at least 30 children and the use of a gold standard for H. pylori diagnosis. In a comprehensive search we identified 68 studies. Subgroup analyses were carried out by technique, immunoglobulin class, and source of test (commercial and in-house). The results demonstrated: 1) WB tests showed high overall performance, sensitivity 91.3% (95% CI, 88.9-93.3), specificity 89% (95% CI, 85.7-91.9), LR+ 8.2 (95% CI, 5.1-13.3), LR- 0.06 (95% CI, 0.02-0.16), DOR 158.8 (95% CI, 57.8-435.8); 2) ELISA-IgG assays showed low sensitivity 79.2% (95% CI, 77.3-81.0) and high specificity (92.4%, 95% CI, 91.6-93.3); 3) ELISA commercial tests varied widely in performance (test for heterogeneity p<0.0001); and 4) In-house ELISA with whole-cell antigen tests showed the highest overall performance: sensitivity 94% (95% CI, 90.2-96.7), specificity 96.4% (95% CI, 94.2-97.9), LR+ 19.9 (95% CI, 7.9-49.8), LR- 0.08 (95% CI, 0.04-0.15) DOR 292.8 (95% CI, 101.8-841.7).WB test and in-house ELISA with whole-cell antigen tests are the most reliable tests for the diagnosis of H. pylori infection in children. Antigens obtained from local strains of the community could partially explain the good overall accuracy of the in-house ELISA. Because of its cost and technical demands, in-house ELISA might be more suitable for use in developing countries." @default.
• W2126658988 created "2016-06-24" @default.
• W2126658988 creator A5008928379 @default.
• W2126658988 creator A5026363980 @default.
• W2126658988 creator A5064559567 @default.
• W2126658988 creator A5069512947 @default.
• W2126658988 creator A5085665231 @default.
• W2126658988 date "2008-11-18" @default.
• W2126658988 modified "2023-10-16" @default.
• W2126658988 title "Antibody-Based Detection Tests for the Diagnosis of Helicobacter pylori Infection in Children: A Meta-Analysis" @default.
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• W2126658988 doi "https://doi.org/10.1371/journal.pone.0003751" @default.

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