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- W2126679920 abstract "Our goal is to generate accurate neuronal models of Alzheimer's and Parkinson's disease for the analysis of disease mechanism and for therapeutic development. No available gene-modified animal models fully recapitulate disease pathology. Furthermore, neuronal models of sporadic disease are limited by the difficulties in obtaining patient neurons. Our goal is to generate accurate neuronal models of Alzheimer's and Parkinson's disease for the analysis of disease mechanism and for therapeutic development. No available gene-modified animal models fully recapitulate disease pathology. Furthermore, neuronal models of ‘sporadic’ disease are limited by the difficulties in obtaining patient neurons. We are developing iPS cell-based models of Alzheimer's and Parkinson's. Briefly, patient-derived skin cells are transduced with a cocktail of reprogramming factor genes using lentiviral vectors, as developed by Yamanakaand colleagues. Additional lines are derived from healthy age-matched controls. We have succeeded in generating iPS cell models of familial and sporadic forms of Alzheimer's disease. These lines have been validated using a number of standard criteria, and neurons can be generated by differentiation protocols. The generation of patient-derived iPS cells, and their differentiation into neurons, may allow for the analysis of cellular and molecular phenotypes relevant to the disease. Furthermore, the method may allow for the investigation of questions such as the role of genetic and epigenetic factors in ‘sporadic’ disease." @default.
- W2126679920 created "2016-06-24" @default.
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- W2126679920 date "2011-07-01" @default.
- W2126679920 modified "2023-09-27" @default.
- W2126679920 title "P1-027: Analysis of iPS cell models of Alzheimer's disease" @default.
- W2126679920 doi "https://doi.org/10.1016/j.jalz.2011.05.307" @default.
- W2126679920 hasPublicationYear "2011" @default.
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