FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2126680686> ?p ?o ?g. }

• W2126680686 endingPage "3378" @default.
• W2126680686 startingPage "3370" @default.
• W2126680686 abstract "Transcriptional alterations are characteristic of persistent pain states, but the key regulators remain elusive. HDAC4 is a transcriptional corepressor that has been linked to synaptic plasticity and neuronal excitability, mechanisms that may be involved in peripheral and central sensitization. Using a conditional knockout (cKO) strategy in mice, we sought to determine whether the loss of HDAC4 would have implications for sensory neuron transcription and nociception. HDAC4 was found to be largely unnecessary for transcriptional regulation of naïve sensory neurons but was essential for appropriate transcriptional responses after injury, with Calca and Trpv1 expression consistently down-regulated in HDAC4 cKO compared to levels in the littermate controls (0.2-0.44-fold change, n = 4 in 2 separate experiments). This down-regulation corresponded to reduced sensitivity to 100 nM capsaicin in vitro (IC50 = 230 ± 20 nM, 76 ± 4.4% wild-type capsaicin responders vs. 56.9 ± 4.7% HDAC4 cKO responders) and to reduced thermal hypersensitivity in the complete Freund's adjuvant (CFA) model of inflammatory pain (1.3-1.4-fold improvement over wild-type controls; n = 5-12, in 2 separate experiments). These data indicate that HDAC4 is a novel inflammatory pain mediator and may be a good therapeutic target, capable of orchestrating the regulation of multiple downstream effectors." @default.
• W2126680686 created "2016-06-24" @default.
• W2126680686 creator A5036506943 @default.
• W2126680686 creator A5040885096 @default.
• W2126680686 creator A5060536734 @default.
• W2126680686 creator A5070263300 @default.
• W2126680686 creator A5072056143 @default.
• W2126680686 creator A5074361716 @default.
• W2126680686 creator A5080195360 @default.
• W2126680686 creator A5084196640 @default.
• W2126680686 creator A5089467171 @default.
• W2126680686 date "2015-08-01" @default.
• W2126680686 modified "2023-10-14" @default.
• W2126680686 title "HDAC4 is required for inflammation-associated thermal hypersensitivity" @default.
• W2126680686 cites W1491378069 @default.
• W2126680686 cites W1546952499 @default.
• W2126680686 cites W1963857381 @default.
• W2126680686 cites W1972640183 @default.
• W2126680686 cites W1982766107 @default.
• W2126680686 cites W1990875610 @default.
• W2126680686 cites W1993317016 @default.
• W2126680686 cites W2007896643 @default.
• W2126680686 cites W2008340135 @default.
• W2126680686 cites W2015363965 @default.
• W2126680686 cites W2018258700 @default.
• W2126680686 cites W2018373513 @default.
• W2126680686 cites W2031926951 @default.
• W2126680686 cites W2040352709 @default.
• W2126680686 cites W2042779242 @default.
• W2126680686 cites W2048890215 @default.
• W2126680686 cites W2076238001 @default.
• W2126680686 cites W2083784041 @default.
• W2126680686 cites W2085796450 @default.
• W2126680686 cites W2090611194 @default.
• W2126680686 cites W2094248609 @default.
• W2126680686 cites W2101556067 @default.
• W2126680686 cites W2102884982 @default.
• W2126680686 cites W2105469906 @default.
• W2126680686 cites W2107277218 @default.
• W2126680686 cites W2126580445 @default.
• W2126680686 cites W2130367422 @default.
• W2126680686 cites W2133338739 @default.
• W2126680686 cites W2133551241 @default.
• W2126680686 cites W2148708580 @default.
• W2126680686 cites W2149599746 @default.
• W2126680686 cites W2153968156 @default.
• W2126680686 cites W2158225056 @default.
• W2126680686 cites W2159426911 @default.
• W2126680686 cites W2162009118 @default.
• W2126680686 cites W2162983470 @default.
• W2126680686 cites W2167613032 @default.
• W2126680686 cites W2170989872 @default.
• W2126680686 cites W2172201406 @default.
• W2126680686 cites W2192080449 @default.
• W2126680686 cites W2410480159 @default.
• W2126680686 doi "https://doi.org/10.1096/fj.14-264440" @default.
• W2126680686 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4511203" @default.
• W2126680686 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25903105" @default.
• W2126680686 hasPublicationYear "2015" @default.
• W2126680686 type Work @default.
• W2126680686 sameAs 2126680686 @default.
• W2126680686 citedByCount "25" @default.
• W2126680686 countsByYear W21266806862016 @default.
• W2126680686 countsByYear W21266806862017 @default.
• W2126680686 countsByYear W21266806862018 @default.
• W2126680686 countsByYear W21266806862019 @default.
• W2126680686 countsByYear W21266806862020 @default.
• W2126680686 countsByYear W21266806862021 @default.
• W2126680686 countsByYear W21266806862022 @default.
• W2126680686 crossrefType "journal-article" @default.
• W2126680686 hasAuthorship W2126680686A5036506943 @default.
• W2126680686 hasAuthorship W2126680686A5040885096 @default.
• W2126680686 hasAuthorship W2126680686A5060536734 @default.
• W2126680686 hasAuthorship W2126680686A5070263300 @default.
• W2126680686 hasAuthorship W2126680686A5072056143 @default.
• W2126680686 hasAuthorship W2126680686A5074361716 @default.
• W2126680686 hasAuthorship W2126680686A5080195360 @default.
• W2126680686 hasAuthorship W2126680686A5084196640 @default.
• W2126680686 hasAuthorship W2126680686A5089467171 @default.
• W2126680686 hasBestOaLocation W21266806862 @default.
• W2126680686 hasConcept C104317684 @default.
• W2126680686 hasConcept C126322002 @default.
• W2126680686 hasConcept C127716648 @default.
• W2126680686 hasConcept C15490471 @default.
• W2126680686 hasConcept C155164980 @default.
• W2126680686 hasConcept C160145004 @default.
• W2126680686 hasConcept C164659718 @default.
• W2126680686 hasConcept C170493617 @default.
• W2126680686 hasConcept C203014093 @default.
• W2126680686 hasConcept C2107291 @default.
• W2126680686 hasConcept C2776217527 @default.
• W2126680686 hasConcept C2776914184 @default.
• W2126680686 hasConcept C2778305200 @default.
• W2126680686 hasConcept C2780051329 @default.
• W2126680686 hasConcept C54355233 @default.
• W2126680686 hasConcept C58793620 @default.
• W2126680686 hasConcept C64927066 @default.
• W2126680686 hasConcept C71924100 @default.

• next