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- W2126682563 abstract "Aim: This study was conducted to investigate the effects of the leaf extract of Citrulluslanatus on carbon tetrachloride (CCl4) induced liver damage in rats.Methodology: Hepatoprotective study was conducted using five groups (A-E) of six malerats per group. Groups A and B served as the control groups and were respectivelyadministered with distilled water and CCl4 in olive oil while groups C, D and E wereadministered respectively with 500, 1,000 and 1,500mg/kg body weight of the ethanolicleaf extract of C. lanatus for 7 days. Animals were subsequently anaesthetized, bloodsamples were collected for alanine amino transferase (ALT), aspartate amino transferase(AST), alkaline phosphatase (ALP), total bilirubin, total protein and albumin assays; liverorgan was isolated and processed for biochemical and histopathological studies.Results: There were significant increases (P=0.05) in the serum levels of ALT and ASTboth in the plasma and liver homogenate in the group treated with CCl4 as compared tonegative control group; while in the extract treated group, there was a decrease in thelevels of the aminotransferases. Histopathological studies showed severe portal congestion and necrosis of hepatocytes in the group treated with CCl4 while the groupsadministered with the extract treated group showed a moderate venous congestion withabsence of necrosis.Conclusion: These results highlight the ability of the leaf extract of C. lanatus toameliorate damage in the liver of albino rats" @default.
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- W2126682563 date "2014-01-10" @default.
- W2126682563 modified "2023-09-26" @default.
- W2126682563 title "Protective Properties of Citrullus lanatus on Carbon Tetrachloride Induced Liver Damage in Rats" @default.
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- W2126682563 doi "https://doi.org/10.9734/ejmp/2014/9690" @default.
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