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- W2126727292 abstract "The hyper-activation of glutamate receptors is a key event in the degenerative processes triggered by ischemia in the brain. Several types of these receptors reside in cholesterol–sphingomyelin rich domains of post-synaptic plasma membranes and have been described to be sensitive to cholesterol depletion. Hence we investigated, by extracellular recordings, the effect of cholesterol depletion on population spikes (PS) during ischemia-like conditions in the CA1 region of rat hippocampal slices using the cholesterol-depleting agent methyl-beta-cyclodextrin (MβCD). Results obtained demonstrate that MβCD prevents the changes induced by anoxic insult, i.e., depression of the population spike amplitude and insurgence of ischemic long-term potentiation. Furthermore cholesterol depletion prevents the disappearance of population spike induced by anoxia/aglycemia during kainate perfusion. Our data suggest a possible role of MβCD in preventing the pathological changes in synaptic activity induced by ischemia and indicate that manipulation of lipid components of membrane rafts might provide a new approach for the treatment of ischemia." @default.
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- W2126727292 date "2009-10-01" @default.
- W2126727292 modified "2023-10-16" @default.
- W2126727292 title "Cholesterol depletion inhibits electrophysiological changes induced by anoxia in CA1 region of rat hippocampal slices" @default.
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- W2126727292 doi "https://doi.org/10.1016/j.brainres.2009.08.037" @default.
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