FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2126735560> ?p ?o ?g. }

• W2126735560 endingPage "1249" @default.
• W2126735560 startingPage "1239" @default.
• W2126735560 abstract "Tamoxifen, a selective estrogen receptor (ER) modulator, is the most widely prescribed hormonal therapy treatment for breast cancer. Despite the benefits of tamoxifen therapy, almost all tamoxifen-responsive breast cancer patients develop resistance to therapy. In addition, tamoxifen displays estrogen-like effects in the endometrium increasing the incidence of endometrial cancer. New therapeutic strategies are needed to circumvent tamoxifen resistance in breast cancer as well as tamoxifen toxicity in endometrium. Organic selenium compounds are highly effective chemopreventive agents with well-documented benefits in reducing total cancer incidence and mortality rates for a number of cancers. The present study shows that the organic selenium compound methylseleninic acid (MSA, 2.5 micromol/L) can potentiate growth inhibition of 4-hydroxytamoxifen (10(-7) mol/L) in tamoxifen-sensitive MCF-7 and T47D breast cancer cell lines. Remarkably, in tamoxifen-resistant MCF-7-LCC2 and MCF7-H2Delta16 breast cancer cell lines and endometrial-derived HEC1A and Ishikawa cells, coincubation of 4-hydroxytamoxifen with MSA resulted in a marked growth inhibition that was substantially greater than MSA alone. Growth inhibition by MSA and MSA + 4-hydroxytamoxifen in all cell lines was preceded by a specific decrease in ER(alpha) mRNA and protein without an effect on ER(beta) levels. Estradiol and 4-hydroxytamoxifen induction of endogenous ER-dependent gene expression (pS2 and c-myc) as well as ER-dependent reporter gene expression (ERE(2)e1b-luciferase) was also attenuated by MSA in all cell lines before effect on growth inhibition. Taken together, these data strongly suggest that specific decrease in ER(alpha) levels by MSA is required for both MSA potentiation of the growth inhibitory effects of 4-hydroxytamoxifen and resensitization of tamoxifen-resistant cell lines." @default.
• W2126735560 created "2016-06-24" @default.
• W2126735560 creator A5004240058 @default.
• W2126735560 creator A5007535547 @default.
• W2126735560 creator A5014408610 @default.
• W2126735560 creator A5022723594 @default.
• W2126735560 creator A5043313553 @default.
• W2126735560 creator A5060144598 @default.
• W2126735560 date "2005-08-01" @default.
• W2126735560 modified "2023-10-16" @default.
• W2126735560 title "Selenium disrupts estrogen receptor α signaling and potentiates tamoxifen antagonism in endometrial cancer cells and tamoxifen-resistant breast cancer cells" @default.
• W2126735560 cites W1524412842 @default.
• W2126735560 cites W1529853088 @default.
• W2126735560 cites W1966203161 @default.
• W2126735560 cites W1971870819 @default.
• W2126735560 cites W1974577953 @default.
• W2126735560 cites W1977839234 @default.
• W2126735560 cites W1991840824 @default.
• W2126735560 cites W1996211461 @default.
• W2126735560 cites W1997006452 @default.
• W2126735560 cites W2001664183 @default.
• W2126735560 cites W2009219941 @default.
• W2126735560 cites W2009583665 @default.
• W2126735560 cites W2019695814 @default.
• W2126735560 cites W2035336181 @default.
• W2126735560 cites W2045389096 @default.
• W2126735560 cites W2065758637 @default.
• W2126735560 cites W2067233094 @default.
• W2126735560 cites W2073353512 @default.
• W2126735560 cites W2078462794 @default.
• W2126735560 cites W2080125447 @default.
• W2126735560 cites W2085124463 @default.
• W2126735560 cites W2091117378 @default.
• W2126735560 cites W2091462786 @default.
• W2126735560 cites W2092974259 @default.
• W2126735560 cites W2094838095 @default.
• W2126735560 cites W2102056087 @default.
• W2126735560 cites W2109388713 @default.
• W2126735560 cites W2112444654 @default.
• W2126735560 cites W2120614127 @default.
• W2126735560 cites W2128840922 @default.
• W2126735560 cites W2138798180 @default.
• W2126735560 cites W2154377786 @default.
• W2126735560 cites W2161623422 @default.
• W2126735560 cites W2167952757 @default.
• W2126735560 cites W4245684785 @default.
• W2126735560 cites W4254096897 @default.
• W2126735560 doi "https://doi.org/10.1158/1535-7163.mct-05-0046" @default.
• W2126735560 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16093440" @default.
• W2126735560 hasPublicationYear "2005" @default.
• W2126735560 type Work @default.
• W2126735560 sameAs 2126735560 @default.
• W2126735560 citedByCount "36" @default.
• W2126735560 countsByYear W21267355602012 @default.
• W2126735560 countsByYear W21267355602013 @default.
• W2126735560 countsByYear W21267355602014 @default.
• W2126735560 countsByYear W21267355602015 @default.
• W2126735560 countsByYear W21267355602016 @default.
• W2126735560 countsByYear W21267355602019 @default.
• W2126735560 countsByYear W21267355602021 @default.
• W2126735560 countsByYear W21267355602023 @default.
• W2126735560 crossrefType "journal-article" @default.
• W2126735560 hasAuthorship W2126735560A5004240058 @default.
• W2126735560 hasAuthorship W2126735560A5007535547 @default.
• W2126735560 hasAuthorship W2126735560A5014408610 @default.
• W2126735560 hasAuthorship W2126735560A5022723594 @default.
• W2126735560 hasAuthorship W2126735560A5043313553 @default.
• W2126735560 hasAuthorship W2126735560A5060144598 @default.
• W2126735560 hasBestOaLocation W21267355601 @default.
• W2126735560 hasConcept C121608353 @default.
• W2126735560 hasConcept C126322002 @default.
• W2126735560 hasConcept C134018914 @default.
• W2126735560 hasConcept C2776067312 @default.
• W2126735560 hasConcept C2777088508 @default.
• W2126735560 hasConcept C2777164284 @default.
• W2126735560 hasConcept C2777176818 @default.
• W2126735560 hasConcept C2777944059 @default.
• W2126735560 hasConcept C2779707156 @default.
• W2126735560 hasConcept C502942594 @default.
• W2126735560 hasConcept C530470458 @default.
• W2126735560 hasConcept C54355233 @default.
• W2126735560 hasConcept C62112901 @default.
• W2126735560 hasConcept C71924100 @default.
• W2126735560 hasConcept C84606932 @default.
• W2126735560 hasConcept C86803240 @default.
• W2126735560 hasConceptScore W2126735560C121608353 @default.
• W2126735560 hasConceptScore W2126735560C126322002 @default.
• W2126735560 hasConceptScore W2126735560C134018914 @default.
• W2126735560 hasConceptScore W2126735560C2776067312 @default.
• W2126735560 hasConceptScore W2126735560C2777088508 @default.
• W2126735560 hasConceptScore W2126735560C2777164284 @default.
• W2126735560 hasConceptScore W2126735560C2777176818 @default.
• W2126735560 hasConceptScore W2126735560C2777944059 @default.
• W2126735560 hasConceptScore W2126735560C2779707156 @default.
• W2126735560 hasConceptScore W2126735560C502942594 @default.
• W2126735560 hasConceptScore W2126735560C530470458 @default.
• W2126735560 hasConceptScore W2126735560C54355233 @default.
• W2126735560 hasConceptScore W2126735560C62112901 @default.

• next