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- W2126739126 abstract "Prime-boost immunization with gene-based vectors has been developed to generate more effective vaccines for AIDS, malaria, and tuberculosis. Although these vectors elicit potent T cell responses, the mechanisms by which they stimulate immunity are not well understood. In this study, we show that immunization by a single gene product, HIV-1 envelope, with alternative vector combinations elicits CD8(+) cells with different fine specificities and kinetics of mobilization. Vaccine-induced CD8(+) T cells recognized overlapping third V region loop peptides. Unexpectedly, two anchor variants bound H-2D(d) better than the native sequences, and clones with distinct specificities were elicited by alternative vectors. X-ray crystallography revealed major differences in solvent exposure of MHC-bound peptide epitopes, suggesting that processed HIV-1 envelope gave rise to MHC-I/peptide conformations recognized by distinct CD8(+) T cell populations. These findings suggest that different gene-based vectors generate peptides with alternative conformations within MHC-I that elicit distinct T cell responses after vaccination." @default.
- W2126739126 created "2016-06-24" @default.
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- W2126739126 date "2009-08-15" @default.
- W2126739126 modified "2023-10-16" @default.
- W2126739126 title "Different Vaccine Vectors Delivering the Same Antigen Elicit CD8+ T Cell Responses with Distinct Clonotype and Epitope Specificity" @default.
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- W2126739126 doi "https://doi.org/10.4049/jimmunol.0900581" @default.
- W2126739126 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2858449" @default.
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- W2126739126 hasPublicationYear "2009" @default.
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