Matches in SemOpenAlex for { <https://semopenalex.org/work/W2126751746> ?p ?o ?g. }
- W2126751746 endingPage "50" @default.
- W2126751746 startingPage "1039" @default.
- W2126751746 abstract "Distribution of inorganic mercury (Hg) into both acid-soluble and protein-bound fractions of proximal tubular (PT) cells from the rat increased with increasing concentrations of Hg up to 10 microM. Little correlation was found between subcellular distribution of Hg and dose in distal tubular (DT) cells. Cellular accumulation of Hg was rapid, reaching equilibrium values by 10 to 15 min. Cellular content of Hg was significantly higher in PT cells than in DT cells at 1 microM Hg. To assess the effect of extracellular thiols on the intracellular accumulation of Hg, PT and DT cells were coincubated with Hg and cysteine, glutathione (GSH), bovine serum albumin (BSA) or 2,3-dimercapto-1-propanesulfonic acid (DMPS) in a 4:1 thiol:Hg molar ratio. Coexposure with Hg and cysteine increased intracellular accumulation of Hg in PT cells at 0.1 microM Hg relative to exposure to Hg alone, consistent with an Hg-cysteine conjugate being a transport form of Hg. In contrast, coexposure with Hg and BSA or DMPS markedly decreased accumulation of Hg relative to cells exposed to Hg alone in both cell types. Coexposure with Hg and GSH also decreased accumulation of Hg relative to exposure to Hg alone, but the decrease was less than coexposure with either BSA or DMPS, suggesting that either an Hg-GSH complex may be a transport form or that some of the Hg-GSH complexes were degraded to Hg-cysteine by the action of brush-border membrane enzymes. These results demonstrate that extracellular thiols markedly alter the renal accumulation of Hg and suggest that some Hg-thiol conjugates may be important physiological transport forms of Hg in the kidney." @default.
- W2126751746 created "2016-06-24" @default.
- W2126751746 creator A5030738786 @default.
- W2126751746 creator A5060737195 @default.
- W2126751746 creator A5091841050 @default.
- W2126751746 date "1998-06-01" @default.
- W2126751746 modified "2023-09-23" @default.
- W2126751746 title "Role of extracellular thiols in accumulation and distribution of inorganic mercury in rat renal proximal and distal tubular cells." @default.
- W2126751746 cites W1489389457 @default.
- W2126751746 cites W1557443776 @default.
- W2126751746 cites W1779061316 @default.
- W2126751746 cites W1906624986 @default.
- W2126751746 cites W1969684499 @default.
- W2126751746 cites W1975829294 @default.
- W2126751746 cites W1993101011 @default.
- W2126751746 cites W1996011720 @default.
- W2126751746 cites W1996148119 @default.
- W2126751746 cites W1998017052 @default.
- W2126751746 cites W2001778733 @default.
- W2126751746 cites W2006488771 @default.
- W2126751746 cites W2006529199 @default.
- W2126751746 cites W2010417078 @default.
- W2126751746 cites W2017295383 @default.
- W2126751746 cites W2024980625 @default.
- W2126751746 cites W2027398521 @default.
- W2126751746 cites W2031604884 @default.
- W2126751746 cites W2040728866 @default.
- W2126751746 cites W2043761262 @default.
- W2126751746 cites W2047065391 @default.
- W2126751746 cites W2051339469 @default.
- W2126751746 cites W2060021923 @default.
- W2126751746 cites W2067668021 @default.
- W2126751746 cites W2070486792 @default.
- W2126751746 cites W2071419639 @default.
- W2126751746 cites W2071570745 @default.
- W2126751746 cites W2071774543 @default.
- W2126751746 cites W2071806271 @default.
- W2126751746 cites W2076317340 @default.
- W2126751746 cites W2077884242 @default.
- W2126751746 cites W2078241781 @default.
- W2126751746 cites W2085717910 @default.
- W2126751746 cites W2091243914 @default.
- W2126751746 cites W2093536322 @default.
- W2126751746 cites W2135940054 @default.
- W2126751746 cites W2150016567 @default.
- W2126751746 cites W2164524746 @default.
- W2126751746 cites W2166354930 @default.
- W2126751746 cites W2178646722 @default.
- W2126751746 cites W2252828241 @default.
- W2126751746 cites W2253570481 @default.
- W2126751746 cites W2272775099 @default.
- W2126751746 cites W2435777848 @default.
- W2126751746 cites W2525840605 @default.
- W2126751746 cites W26645608 @default.
- W2126751746 cites W54928148 @default.
- W2126751746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9618406" @default.
- W2126751746 hasPublicationYear "1998" @default.
- W2126751746 type Work @default.
- W2126751746 sameAs 2126751746 @default.
- W2126751746 citedByCount "12" @default.
- W2126751746 countsByYear W21267517462016 @default.
- W2126751746 countsByYear W21267517462018 @default.
- W2126751746 crossrefType "journal-article" @default.
- W2126751746 hasAuthorship W2126751746A5030738786 @default.
- W2126751746 hasAuthorship W2126751746A5060737195 @default.
- W2126751746 hasAuthorship W2126751746A5091841050 @default.
- W2126751746 hasConcept C130316041 @default.
- W2126751746 hasConcept C181199279 @default.
- W2126751746 hasConcept C185592680 @default.
- W2126751746 hasConcept C199360897 @default.
- W2126751746 hasConcept C2776125364 @default.
- W2126751746 hasConcept C2777777548 @default.
- W2126751746 hasConcept C2779201268 @default.
- W2126751746 hasConcept C2781324293 @default.
- W2126751746 hasConcept C28406088 @default.
- W2126751746 hasConcept C41008148 @default.
- W2126751746 hasConcept C41625074 @default.
- W2126751746 hasConcept C538909803 @default.
- W2126751746 hasConcept C5426402 @default.
- W2126751746 hasConcept C55493867 @default.
- W2126751746 hasConcept C79879829 @default.
- W2126751746 hasConcept C86807702 @default.
- W2126751746 hasConceptScore W2126751746C130316041 @default.
- W2126751746 hasConceptScore W2126751746C181199279 @default.
- W2126751746 hasConceptScore W2126751746C185592680 @default.
- W2126751746 hasConceptScore W2126751746C199360897 @default.
- W2126751746 hasConceptScore W2126751746C2776125364 @default.
- W2126751746 hasConceptScore W2126751746C2777777548 @default.
- W2126751746 hasConceptScore W2126751746C2779201268 @default.
- W2126751746 hasConceptScore W2126751746C2781324293 @default.
- W2126751746 hasConceptScore W2126751746C28406088 @default.
- W2126751746 hasConceptScore W2126751746C41008148 @default.
- W2126751746 hasConceptScore W2126751746C41625074 @default.
- W2126751746 hasConceptScore W2126751746C538909803 @default.
- W2126751746 hasConceptScore W2126751746C5426402 @default.
- W2126751746 hasConceptScore W2126751746C55493867 @default.
- W2126751746 hasConceptScore W2126751746C79879829 @default.
- W2126751746 hasConceptScore W2126751746C86807702 @default.